CHAETOMIN
- Product Name
- CHAETOMIN
- CAS No.
- 1403-36-7
- Chemical Name
- CHAETOMIN
- Synonyms
- CTM;CS-1;HSF4;SSFA2;CHETOMIN;CHAETOMIN;NSC 289491;CHETOMIN(RG);DKFZp313O1039;Chetomin,Chaetomin
- CBNumber
- CB4173948
- Molecular Formula
- C31H30N6O6S4
- Formula Weight
- 710.87
- MOL File
- 1403-36-7.mol
CHAETOMIN Property
- Melting point:
- 218-220℃ (chloroform )
- Density
- 1.78±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble
- form
- Off-white to fawn solid.
- pka
- 12.69±0.10(Predicted)
- color
- Off-white to fawn
N-Bromosuccinimide Price
- Product number
- C9623
- Product name
- Chetomin
- Purity
- from Chaetomium cochliodes, ≥98% (HPLC)
- Packaging
- 1mg
- Price
- $265
- Updated
- 2024/03/01
- Product number
- SAB1403947
- Product name
- Monoclonal Anti-HSF4 antibody produced in mouse
- Purity
- clone 3G3, purified immunoglobulin, buffered aqueous solution
- Packaging
- 100μg
- Price
- $524
- Updated
- 2024/03/01
- Product number
- C9623
- Product name
- Chetomin
- Purity
- from Chaetomium cochliodes, ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $792
- Updated
- 2024/03/01
- Product number
- 14437
- Product name
- Chetomin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- 14437
- Product name
- Chetomin
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $549
- Updated
- 2024/03/01
CHAETOMIN Chemical Properties,Usage,Production
Uses
Chetomin is an antibacterial agent and inhibitor of HIF.
Definition
ChEBI: An organic heteropentacyclic compound of the class of epipolythiodioxopiperazine. Isolated from Chaetomium globosum and Farrowia seminuda, it exhibits immunosuppressive activity.
Biochem/physiol Actions
Chetomin is a natural metabolite produced by several species of the genus Chaetomium. Chetomin is an epidithiodioxopiperazine known to disrupt the hypoxia-inducible factor (HIF) pathway. Chetomin blocks the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Disrupting the ability of tumors to adapt to hypoxia leads to decreased tumor growth and can serve as an antitumor stratagy. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes.
storage
+4°C