2,3-Dimethylbenzoic acid
- Product Name
- 2,3-Dimethylbenzoic acid
- CAS No.
- 603-79-2
- Chemical Name
- 2,3-Dimethylbenzoic acid
- Synonyms
- hemelliticacid;Hemellitic acid;RARECHEM AL BO 0357;vic.-o-xylylic acid;2,3-dimethylbenzoate;2,3-dimethyl-benzoicaci;2,3-DIMETHYLBENZOIC ACID;O-XYLENE-3-CARBOXYLIC ACID;Benzoicacid, 2,3-dimethyl-;2,3-DimethylbenzoicAcid>
- CBNumber
- CB9768297
- Molecular Formula
- C9H10O2
- Formula Weight
- 150.17
- MOL File
- 603-79-2.mol
2,3-Dimethylbenzoic acid Property
- Melting point:
- 144-146 °C (lit.)
- Boiling point:
- 271.51°C (estimate)
- Density
- 1.0937 (estimate)
- refractive index
- 1.5188 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- pKa: 3.771(25°C)
- color
- White to Almost white
- BRN
- 971590
- InChI
- InChI=1S/C9H10O2/c1-6-4-3-5-8(7(6)2)9(10)11/h3-5H,1-2H3,(H,10,11)
- InChIKey
- RIZUCYSQUWMQLX-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=CC(C)=C1C
- CAS DataBase Reference
- 603-79-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzoic acid, 2,3-dimethyl-(603-79-2)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-36/37/39-22
- WGK Germany
- 3
- RTECS
- DG8734000
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 138150
- Product name
- 2,3-Dimethylbenzoic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $38
- Updated
- 2025/07/31
- Product number
- 138150
- Product name
- 2,3-Dimethylbenzoic acid
- Purity
- 98%
- Packaging
- 25g
- Price
- $127
- Updated
- 2023/01/07
- Product number
- D2221
- Product name
- 2,3-Dimethylbenzoic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $24
- Updated
- 2025/07/31
- Product number
- D2221
- Product name
- 2,3-Dimethylbenzoic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $69
- Updated
- 2025/07/31
- Product number
- D464670
- Product name
- 2,3-Dimethylbenzoic Acid
- Packaging
- 50g
- Price
- $155
- Updated
- 2021/12/16
2,3-Dimethylbenzoic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
2,3-Dimethylbenzoic Acid is used as a reagent in the synthesis of pyridyl benzamides as inhibitors for the kinetoplastid Trypanosoma brucei. 2,3-Dimethylbenzoic Acid is also used as a reagent in the synthesis of 2,3-Dihydro-1H-isoindole-4-carboxylic Acid (D450070) which is a reagent used in the synthesis of aminoalkylbenzoic acid derivatives for the treatment of faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, neuropathic pain, neuropathological disorders and sleep disorders.
Definition
ChEBI: A dimethylbenzoic acid in which the two methyl groups are located at positions 2 and 3.
General Description
2,3-Dimethylbenzoic acid shows high binding affinity with antenna-specific odorant-binding protein of the alfalfa plant bug, Adelphocoris lineolatus.
Synthesis
95-47-6
124-38-9
603-79-2
1. 40 mL of dry o-xylene was rapidly added to a 250 mL PTFE-lined autoclave under argon protection. 2. 2.5 g of anhydrous aluminum trichloride (AlCl3) and 1.16 g of dry N-butylimidazole were added sequentially. Add 2.5 g of anhydrous aluminum trichloride (AlCl3) and 1.16 g of dry N-butylimidazole sequentially, and seal the reaction vessel after addition. 2. Connect a carbon dioxide cylinder to the autoclave through a pipeline, adjust the valve so that the CO2 pressure is maintained at 6 MPa, start the stirrer, and set the rotation speed at 1,000 rpm, and then begin to heat the system to 40°C, and the reaction lasts for 48 hours. 3. At the end of the reaction, 150 mL of water was added to the system and stirred for 30 min. 4. The reaction mixture was extracted three times with 50 mL of ether, and the organic phases were combined, concentrated and dried to give 2.76 g of an off-white solid, i.e., crude 2,3-dimethylbenzoic acid. 5. The above crude product was dissolved in 20 mL of a 10% (w/w) sodium hydroxide solution, and filtered to remove insoluble matter, to give a filtrate. 6. The filtrate was extracted with 1 mol/L hydrochloric acid to adjust the pH of the filtrate to 1 and let it stand at room temperature for 60 min. 7. The mixture was transferred to -10°C for further crystallization and filtered to obtain crystals. 8. The crystals were dried to obtain 2.29 g of white solid 2,3-dimethylbenzoic acid in 81.3% yield.
Purification Methods
Crystallise the acid from EtOH. It is volatile in steam. The amide has m 156o (from H2O). [Beilstein 9 H 531, 9 III 2434, 9 IV 1797.]
References
[1] Patent: CN107827742, 2018, A. Location in patent: Paragraph 0059; 0060
2,3-Dimethylbenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-Dimethylbenzoic acid manufacturers
- Product
- 2,3-Dimethylbenzoic acid 603-79-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-19
- Product
- Medetomidine Impurity 20 603-79-2
- Price
- US $0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-03-27
- Product
- Medetomidine Impurity 603-79-2
- Price
- US $0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-03-27