20-CARBOXY-LEUKOTRIENE B4 Property

Boiling point:

588.3±50.0 °C(Predicted)

Density 

1.151±0.06 g/cm3(Predicted)

Flash point:

14℃

storage temp. 

−20°C

solubility 

DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml

form 

Liquid

pka

4.66±0.10(Predicted)

color 

Colorless to light yellow

Safety

Hazard Codes 

F,Xi

Risk Statements 

11-36/37/38

Safety Statements 

16-26-36

RIDADR 

UN 1170 3/PG 2

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

20-CARBOXY-LEUKOTRIENE B4 Chemical Properties,Usage,Production

Description

20-carboxy LTB₄ is a metabolite of LTB₄ in human neutrophils. In human leukocytes, LTB₄ is inactivated by the enzyme LTB₄ 20-hydroxylase. The resulting 20-hydroxy LTB₄ is further oxidized to 20-carboxy LTB₄. LTB₄ metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB₄ along with other ω-oxidation products. The biological activity of 20-carboxy LTB₄ is only about 2.6% compared to that of LTB₄ in causing PMNL degranulation.

Uses

20-COOH-LTB4 is a leukotriene B4 metabolite and substrate for β-oxidation pathways.

Definition

ChEBI: A member of the class of leukotrienes that is leukotriene B4 in which the terminal methyl group has undergone formal oxidation to the corresponding carboxylic acid.