3-HYDROXY-5-METHOXYBENZOIC ACID

Product Name: 3-HYDROXY-5-METHOXYBENZOIC ACID
CAS No.: 19520-75-3
Chemical Name: 3-HYDROXY-5-METHOXYBENZOIC ACID
Synonyms: 19520-75-3;AKOS 214-12;3-HYDROXY-5-METHOXYBENZOIC ACID;Benzoic acid, 3-hydroxy-5-methoxy-;3-hydroxy-5-methoxybenzenemacetic acid
CBNumber: CB9777990
Molecular Formula: C8H8O4
Formula Weight: 168.15
MOL File: 19520-75-3.mol

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3-HYDROXY-5-METHOXYBENZOIC ACID Property

Melting point:: 202-203 °C
Boiling point:: 394.7±27.0 °C(Predicted)
Density: 1.351±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 3.96±0.10(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: H855050
Product name: 3-Hydroxy-5-methoxybenzoicacid
Packaging: 50mg
Price: $220
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0389191
Product name: 3-HYDROXY-5-METHOXYBENZOIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $500.41
Updated: 2021/12/16

Crysdot

Product number: CD12100136
Product name: 3-Hydroxy-5-methoxybenzoicacid
Purity: 95+%
Packaging: 1g
Price: $767
Updated: 2021/12/16

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3-HYDROXY-5-METHOXYBENZOIC ACID Chemical Properties,Usage,Production

Definition

ChEBI: 3-hydroxy-5-methoxybenzoic acid is a methoxybenzoic acid.

Synthesis

19520-74-2

19520-75-3

GENERAL METHOD: Methyl 3-hydroxy-5-methoxybenzoate (4.5 g, 16.7 mmol) was dissolved in methanol (30 mL) and 1M sodium hydroxide solution (60 mL, 60 mmol) was added under nitrogen protection. The reaction mixture was stirred at 45 °C for 1-2 h. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction solution was acidified with 1 M hydrochloric acid (50 mL) and subsequently extracted with ethyl acetate (3 x 50 mL). The organic phases were combined, washed with distilled water (2 × 30 mL) and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give 3-hydroxy-5-methoxybenzoic acid (5a) as an off-white solid (4.02 g, 94% yield) with a melting point of 196-198 °C.1H NMR (400 MHz, acetone-d6) δ (ppm): 7.42-7.33 (5H, m, benzyl Ph), 7.21 (1H, dd, J = 2.4,1.2 Hz. H-2), 7.11 (1H, dd, J = 2.4,1.2Hz, H-6), 6.68 (1H, t, J = 2.4Hz, H-4), 5.07 (2H, s, benzyl CH2). The obtained 1H NMR spectrum is in agreement with data reported in the literature [38].

References

[1] European Journal of Medicinal Chemistry, 2013, vol. 63, p. 415 - 422
[2] Journal of the American Chemical Society, 2005, vol. 127, # 6, p. 1737 - 1743
[3] Acta Phytochimica, 1939, vol. 11, p. 167,179

3-HYDROXY-5-METHOXYBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3-HYDROXY-5-METHOXYBENZOIC ACID Suppliers

China 28 Germany 1 The Netherlands 1 Global 30

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19520-75-3, 3-HYDROXY-5-METHOXYBENZOIC ACIDRelated Search:

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3-HYDROXY-5-METHOXYBENZOIC ACID

AKOS 214-12

19520-75-3

Benzoic acid, 3-hydroxy-5-methoxy-

3-hydroxy-5-methoxybenzenemacetic acid

19520-75-3