2-HYDRAZINOBENZOTHIAZOLE
- Product Name
- 2-HYDRAZINOBENZOTHIAZOLE
- CAS No.
- 615-21-4
- Chemical Name
- 2-HYDRAZINOBENZOTHIAZOLE
- Synonyms
- 2 HzBTZ;2-HzBTZ;IDO1-IN-1;AKOS B003351;AKOS BC-3071;IDO1 inhibitor 1;IDO1-inhibitor-1;AKOS BBS-00007373;IFLAB-BB F0896-0067;SALOR-INT L482064-1EA
- CBNumber
- CB9782736
- Molecular Formula
- C7H7N3S
- Formula Weight
- 165.22
- MOL File
- 615-21-4.mol
2-HYDRAZINOBENZOTHIAZOLE Property
- Melting point:
- 198-202 °C (lit.)
- Boiling point:
- 352.4±25.0 °C(Predicted)
- Density
- 1.2404 (rough estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- Solubility in hot methanol almost transparent.
- pka
- 2.81±0.20(Predicted)
- form
- powder to crystal
- color
- White to Light yellow to Light orange
- InChI
- InChI=1S/C7H7N3S/c8-10-7-9-5-3-1-2-4-6(5)11-7/h1-4H,8H2,(H,9,10)
- InChIKey
- JYSUYJCLUODSLN-UHFFFAOYSA-N
- SMILES
- S1C2=CC=CC=C2N=C1NN
- CAS DataBase Reference
- 615-21-4(CAS DataBase Reference)
- EPA Substance Registry System
- 2(3H)-Benzothiazolone, hydrazone (615-21-4)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 642436
- Product name
- 2-Hydrazinobenzothiazole
- Purity
- 97%
- Packaging
- 5g
- Price
- $77.7
- Updated
- 2025/07/31
- Product number
- 642436
- Product name
- 2-Hydrazinobenzothiazole
- Purity
- 97%
- Packaging
- 25g
- Price
- $298
- Updated
- 2023/06/20
- Product number
- H0177
- Product name
- 2-Hydrazinobenzothiazole
- Purity
- >99.0%(T)
- Packaging
- 5g
- Price
- $53
- Updated
- 2025/07/31
- Product number
- H0177
- Product name
- 2-Hydrazinobenzothiazole
- Purity
- >99.0%(T)
- Packaging
- 25g
- Price
- $142
- Updated
- 2025/07/31
- Product number
- H999798
- Product name
- 2-Hydrazinylbenzo[d]thiazole
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
2-HYDRAZINOBENZOTHIAZOLE Chemical Properties,Usage,Production
Chemical Properties
slightly yellow to beige-green crystalline powder
Uses
It is employed in the spectrophotometric analysis determination of methenamine and its salts. It is also used in the detection and repair mechanism of Etheno-DNA adducts.
Synthesis
136-95-8
615-21-4
General procedure for the synthesis of 2-hydrazinobenzothiazole from 2-aminobenzothiazole: Hydrazine hydrate (1 equiv.) was dissolved in ethylene glycol at 5 °C. Under stirring, concentrated hydrochloric acid (2 mL) was added slowly and dropwise, followed by 2-aminobenzothiazole (1 eq.). The reaction mixture was heated to reflux for 2-3 hours, after which it was cooled to room temperature. Upon completion of the reaction, the solid product formed was collected by filtration, washed with water and purified by recrystallization from ethanol to afford the target compound 2-hydrazinobenzo[d]thiazole (32). The product was white crystals in 90% yield with a melting point ranging from 200 °C to 202 °C. 1H NMR (DMSO-d6, 400 MHz) data were as follows: δ 4.84 (2H, s), 6.85-7.65 (4H, m), 8.62 (1H, s). ESI-MS (m/z) analysis showed the molecular ion peak as 166 (MH+).
References
[1] Helvetica Chimica Acta, 1980, vol. 63, # 3, p. 682 - 692
[2] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 418 - 428
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 14, p. 4022 - 4025
[4] Medicinal Chemistry Research, 2012, vol. 21, # 9, p. 2428 - 2442
[5] Journal of Molecular Structure, 2014, vol. 1060, # 1, p. 215 - 222
2-HYDRAZINOBENZOTHIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-HYDRAZINOBENZOTHIAZOLE manufacturers
- Product
- 2-HYDRAZINOBENZOTHIAZOLE 615-21-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2025-09-30
- Product
- 2-Hydrazinobenzothiazole 615-21-4
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 100KG
- Release date
- 2025-08-20
- Product
- 2-Hydrazinobenzothiazole 615-21-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27