SARAFOTOXIN S6C

Product Name: SARAFOTOXIN S6C
CAS No.: 121695-87-2
Chemical Name: SARAFOTOXIN S6C
Synonyms: SRTX-C;SRTX-C, S6C;SARAFOTOXIN C;SARAFOTOXIN 6C;SARAFOTOXIN S6C;CTCNDMTDEECLNFCHQDVIW;Sarafotoxin C, SRTX-C;Sarafotoxin S6c >=97% (HPLC);Sarafotoxin S6c (0.1mg vial);M.W. 2516.00 C103H147N37O27S5
CBNumber: CB9783324
Molecular Formula: C103H147N27O37S5
Formula Weight: 2515.75
MOL File: 121695-87-2.mol

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SARAFOTOXIN S6C Property

storage temp.: -20°C
solubility: DMSO: Sparingly Soluble: 1-10 mg/ml
form: solid
color: white
Water Solubility: Soluble to 1 mg/ml in water

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P284Wear respiratory protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S6545
Product name: Sarafotoxin S6c
Purity: ≥97% (HPLC)
Packaging: 250μg
Price: $958
Updated: 2025/07/31

Sigma-Aldrich

Product number: S6545
Product name: Sarafotoxin S6c
Purity: ≥97% (HPLC)
Packaging: 0.5mg
Price: $1720
Updated: 2025/07/31

Tocris

Product number: 1175
Product name: Sarafotoxin S6c
Packaging: 100U
Price: $208
Updated: 2021/12/16

Usbiological

Product number: 256605
Product name: Sarafotoxin S6c
Packaging: 100ug
Price: $460
Updated: 2021/12/16

Usbiological

Product number: S0170-01B
Product name: Sarafotoxin S6c
Packaging: 1mg
Price: $531
Updated: 2021/12/16

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SARAFOTOXIN S6C Chemical Properties,Usage,Production

Uses

Sarafotoxin S6c (SRTX-c) is a potent endothelin-B receptor agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1].

Biochem/physiol Actions

Sarafotoxin S6c is an endothelin ETB agonist. It is a peptide isotoxin with strong vasoconstrictor activity, obtained from the Middle Eastern snake, Atractaspis engaddensi. The toxin is composed of 21 amino acids.

in vivo

Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels^[1].

Animal Model:	Male Wister rats, exposed to 10% O₂ [chronic hypoxic (CH) rats] or room air (control rats) for 2 weeks^[1]
Dosage:	1 pM-1 mM
Administration:
Result:	Chronic hypoxia had effect on the sensitivity of the main pulmonary arteries to SCS6c, and small vasoconstrictor responses to were evident. Caused vasoconstriction with a maximum response 30% of that to ET-1 in both endothelium-intact and endothelium-denuded vessels.

storage

-20°C

References

[1] MacLean MR, et al. Effects of pulmonary hypertension on vasoconstrictor responses to endothelin-1 and sarafotoxin S6C and on inherent tone in rat pulmonary arteries. J Cardiovasc Pharmacol. 1995 Nov;26(5):822-30. DOI:10.1097/00005344-199511000-00020
[2] CHIKAHISA TAKASAKI . Sarafotoxins S6: Several isotoxins from Atractaspis engaddensis (burrowing asp) venom that affect the heart[J]. Toxicon, 1988, 26 6: Pages 543-548. DOI: 10.1016/0041-0101(88)90234-6
[3] DAVID L. WILLIAMS JR. Sarafotoxin S6c: An agonist which distinguishes between endothelin receptor subtypes[J]. Biochemical and biophysical research communications, 1991, 175 2: Pages 556-561. DOI: 10.1016/0006-291x(91)91601-8
[4] J. BALWIERCZAK. Characterization of a Potent and Selective Endothelin‐B Receptor Antagonist, IRL 2500[J]. Journal of Cardiovascular Pharmacology, 1995, 26 1: S393-396. DOI: 10.1097/00005344-199506263-00116

SARAFOTOXIN S6C Preparation Products And Raw materials

Raw materials

Preparation Products

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SARAFOTOXIN S6C Suppliers

China 105 Europe 1 France 1 Germany 2 Japan 1 Switzerland 3 United Kingdom 3 United States 12 Global 128

3B Pharmachem (Wuhan) International Co.,Ltd.

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Sigma-Aldrich

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Creative Peptides

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121695-87-2, SARAFOTOXIN S6CRelated Search:

SARALASIN SARAFOTOXIN S6D SARAFOTOXIN S6A1,SARAFOTOXIN A,SARAFOTOXIN S6A (ATRACTASPIS ENGADDENSIS),SARAFOTOXIN S6A,SARAFOTOXIN A (ATRACTASPIS ENGADDENSIS) SARAFOTOXIN S6B,SARAFOTOXIN S6B (ATRACTASPIS ENGADDENSIS),SARAFOTOXIN S6B ATRACTASPIS ENGADDENSIS SEQUENCE,SARAFOTOXIN B,SARAFOTOXIN B (ATRACTASPIS ENGADDENSIS) Dipeptide-2 SARAFOTOXIN S6C (NLE6)-SARAFOTOXIN C Sarafotoxin S6b【reduced】 [LYS4]-SARAFOTOXIN 6C H-ILE-TRP-OH [LYS4] SARAFOTOXIN S6C,Sarafotoxin S 6c【reduced】,Sarafotoxin c【reduced】,SARAFOTOXIN 6C, [LYS4]- Sarafotoxin a【reduced】,Sarafotoxin S 6a【reduced】 Sarafotoxin S6b, Atractaspsis engaddensis sarafotoxin receptor Sarafotoxin S6d(16-21) [Asn4]sarafotoxin S6b【reduced】 ANTI-SARAFOTOXIN B [Thr2]sarafotoxin S6b【reduced】

SRTX-C

SARAFOTOXIN S6C

SARAFOTOXIN S6C (ATRACTASPIS ENGADDENSIS)

Sarafotoxin C trifluoroacetate salt

SARAFOTOXIN S6C, ATRACTASPSIS ENGADDENSIS

SARAFOTOXIN 6C

SARAFOTOXIN C

SARAFOTOXIN C (ATRACTASPIS ENGADDENSIS)

CYS-THR-CYS-ASN-ASP-MET-THR-ASP-GLU-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP

CTCNDMTDEECLNFCHQDVIW

CTCNDMTDEECLNFCHQDVIW (DISULFIDE BRIDGE: 1-15 AND 3-11)

H-CYS-THR-CYS-ASN-ASP-MET-THR-ASP-GLU-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP-OH

H-CYS-THR-CYS-ASN-ASP-MET-THR-ASP-GLU-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP-OH (DISULFIDE BRIDGE: 1-15 AND 3-11)

H-CYS-THR-CYS-ASN-ASP-MET-THR-ASP-GLU-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP-OH-OH

SARAFOTOXIN 6C, (LYS4) SYNTHETIC >99% PU RITY

SARAFOTOXIN 6C SYNTHETIC >99% PURITY

M.W. 2516.00 C103H147N37O27S5

CYS-THR-CYS-ASN-ASP-MET-THR-ASP-GLU-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP(DISULFIDE BRIDGE: CYS1-CYS15, CYS3-CYS11)

Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp (Disulfide bridges Cys1-Cys15 and Cys3-Cys11)

SRTX-C, S6C

Sarafotoxin C, SRTX-C

L-Tryptophan, L-cysteinyl-L-threonyl-L-cysteinyl-L-asparaginyl-L-α-aspartyl-L-methionyl-L-threonyl-L-α-aspartyl-L-α-glutamyl-L-α-glutamyl-L-cysteinyl-L-leucyl-L-asparaginyl-L-phenylalanyl-L-cysteinyl-L-histidyl-L-glutaminyl-L-α-aspartyl-L-valyl-L-isoleucyl-, cyclic (1→15),(3→11)-bis(disulfide)

Sarafotoxin S6c >=97% (HPLC)

Sarafotoxin S6c trifluoroacetate salt

Sarafotoxin S6c (0.1mg vial)

121695-87-2

C103H147N27O37S5

C103H147O37N27S5

Peptides

Other Peptides

Endothelins

BioChemical

Agonist

Biochemicals and Reagents

Amino Acids and Peptides

Peptide

Endothelin receptor