ChemicalBook > CAS DataBase List > SARAFOTOXIN S6C

SARAFOTOXIN S6C

Product Name
SARAFOTOXIN S6C
CAS No.
121695-87-2
Chemical Name
SARAFOTOXIN S6C
Synonyms
SRTX-C;SRTX-C, S6C;SARAFOTOXIN C;SARAFOTOXIN 6C;SARAFOTOXIN S6C;CTCNDMTDEECLNFCHQDVIW;Sarafotoxin C, SRTX-C;Sarafotoxin S6c >=97% (HPLC);Sarafotoxin S6c (0.1mg vial);M.W. 2516.00 C103H147N37O27S5
CBNumber
CB9783324
Molecular Formula
C103H147N27O37S5
Formula Weight
2515.75
MOL File
121695-87-2.mol
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SARAFOTOXIN S6C Property

storage temp. 
-20°C
solubility 
DMSO: Sparingly Soluble: 1-10 mg/ml
form 
solid
color 
white
Water Solubility 
Soluble to 1 mg/ml in water
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P284Wear respiratory protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S6545
Product name
Sarafotoxin S6c
Purity
≥97% (HPLC)
Packaging
250μg
Price
$958
Updated
2025/07/31
Sigma-Aldrich
Product number
S6545
Product name
Sarafotoxin S6c
Purity
≥97% (HPLC)
Packaging
0.5mg
Price
$1720
Updated
2025/07/31
Tocris
Product number
1175
Product name
Sarafotoxin S6c
Packaging
100U
Price
$208
Updated
2021/12/16
Usbiological
Product number
256605
Product name
Sarafotoxin S6c
Packaging
100ug
Price
$460
Updated
2021/12/16
Usbiological
Product number
S0170-01B
Product name
Sarafotoxin S6c
Packaging
1mg
Price
$531
Updated
2021/12/16
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SARAFOTOXIN S6C Chemical Properties,Usage,Production

Uses

Sarafotoxin S6c (SRTX-c) is a potent endothelin-B receptor agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1].

Biochem/physiol Actions

Sarafotoxin S6c is an endothelin ETB agonist. It is a peptide isotoxin with strong vasoconstrictor activity, obtained from the Middle Eastern snake, Atractaspis engaddensi. The toxin is composed of 21 amino acids.

in vivo

Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1].

Animal Model:Male Wister rats, exposed to 10% O2 [chronic hypoxic (CH) rats] or room air (control rats) for 2 weeks[1]
Dosage:1 pM-1 mM
Administration:
Result:Chronic hypoxia had effect on the sensitivity of the main pulmonary arteries to SCS6c, and small vasoconstrictor responses to were evident.
Caused vasoconstriction with a maximum response 30% of that to ET-1 in both endothelium-intact and endothelium-denuded vessels.

storage

-20°C

References

[1] MacLean MR, et al. Effects of pulmonary hypertension on vasoconstrictor responses to endothelin-1 and sarafotoxin S6C and on inherent tone in rat pulmonary arteries. J Cardiovasc Pharmacol. 1995 Nov;26(5):822-30. DOI:10.1097/00005344-199511000-00020
[2] CHIKAHISA TAKASAKI . Sarafotoxins S6: Several isotoxins from Atractaspis engaddensis (burrowing asp) venom that affect the heart[J]. Toxicon, 1988, 26 6: Pages 543-548. DOI: 10.1016/0041-0101(88)90234-6
[3] DAVID L. WILLIAMS JR. Sarafotoxin S6c: An agonist which distinguishes between endothelin receptor subtypes[J]. Biochemical and biophysical research communications, 1991, 175 2: Pages 556-561. DOI: 10.1016/0006-291x(91)91601-8
[4] J. BALWIERCZAK. Characterization of a Potent and Selective Endothelin‐B Receptor Antagonist, IRL 2500[J]. Journal of Cardiovascular Pharmacology, 1995, 26 1: S393-396. DOI: 10.1097/00005344-199506263-00116

SARAFOTOXIN S6C Preparation Products And Raw materials

Raw materials

Preparation Products

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SARAFOTOXIN S6C Suppliers

China 105 Europe 1 France 1 Germany 2 Japan 1 Switzerland 3 United Kingdom 3 United States 12 Global 128
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AXXORA, LLC
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121695-87-2, SARAFOTOXIN S6CRelated Search:

SARALASIN SARAFOTOXIN S6D SARAFOTOXIN S6A1,SARAFOTOXIN A,SARAFOTOXIN S6A (ATRACTASPIS ENGADDENSIS),SARAFOTOXIN S6A,SARAFOTOXIN A (ATRACTASPIS ENGADDENSIS) SARAFOTOXIN S6B,SARAFOTOXIN S6B (ATRACTASPIS ENGADDENSIS),SARAFOTOXIN S6B ATRACTASPIS ENGADDENSIS SEQUENCE,SARAFOTOXIN B,SARAFOTOXIN B (ATRACTASPIS ENGADDENSIS) Dipeptide-2 SARAFOTOXIN S6C (NLE6)-SARAFOTOXIN C Sarafotoxin S6b【reduced】 [LYS4]-SARAFOTOXIN 6C H-ILE-TRP-OH [LYS4] SARAFOTOXIN S6C,Sarafotoxin S 6c【reduced】,Sarafotoxin c【reduced】,SARAFOTOXIN 6C, [LYS4]- Sarafotoxin a【reduced】,Sarafotoxin S 6a【reduced】 Sarafotoxin S6b, Atractaspsis engaddensis sarafotoxin receptor Sarafotoxin S6d(16-21) [Asn4]sarafotoxin S6b【reduced】 ANTI-SARAFOTOXIN B [Thr2]sarafotoxin S6b【reduced】

  • SRTX-C
  • SARAFOTOXIN S6C
  • SARAFOTOXIN S6C (ATRACTASPIS ENGADDENSIS)
  • Sarafotoxin C trifluoroacetate salt
  • SARAFOTOXIN S6C, ATRACTASPSIS ENGADDENSIS
  • SARAFOTOXIN 6C
  • SARAFOTOXIN C
  • SARAFOTOXIN C (ATRACTASPIS ENGADDENSIS)
  • CYS-THR-CYS-ASN-ASP-MET-THR-ASP-GLU-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP
  • CTCNDMTDEECLNFCHQDVIW
  • CTCNDMTDEECLNFCHQDVIW (DISULFIDE BRIDGE: 1-15 AND 3-11)
  • H-CYS-THR-CYS-ASN-ASP-MET-THR-ASP-GLU-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP-OH
  • H-CYS-THR-CYS-ASN-ASP-MET-THR-ASP-GLU-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP-OH (DISULFIDE BRIDGE: 1-15 AND 3-11)
  • H-CYS-THR-CYS-ASN-ASP-MET-THR-ASP-GLU-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP-OH-OH
  • SARAFOTOXIN 6C, (LYS4) SYNTHETIC >99% PU RITY
  • SARAFOTOXIN 6C SYNTHETIC >99% PURITY
  • M.W. 2516.00 C103H147N37O27S5
  • CYS-THR-CYS-ASN-ASP-MET-THR-ASP-GLU-GLU-CYS-LEU-ASN-PHE-CYS-HIS-GLN-ASP-VAL-ILE-TRP(DISULFIDE BRIDGE: CYS1-CYS15, CYS3-CYS11)
  • Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp (Disulfide bridges Cys1-Cys15 and Cys3-Cys11)
  • SRTX-C, S6C
  • Sarafotoxin C, SRTX-C
  • L-Tryptophan, L-cysteinyl-L-threonyl-L-cysteinyl-L-asparaginyl-L-α-aspartyl-L-methionyl-L-threonyl-L-α-aspartyl-L-α-glutamyl-L-α-glutamyl-L-cysteinyl-L-leucyl-L-asparaginyl-L-phenylalanyl-L-cysteinyl-L-histidyl-L-glutaminyl-L-α-aspartyl-L-valyl-L-isoleucyl-, cyclic (1→15),(3→11)-bis(disulfide)
  • Sarafotoxin S6c >=97% (HPLC)
  • Sarafotoxin S6c trifluoroacetate salt
  • Sarafotoxin S6c (0.1mg vial)
  • 121695-87-2
  • C103H147N27O37S5
  • C103H147O37N27S5
  • Peptides
  • Other Peptides
  • Endothelins
  • BioChemical
  • Agonist
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • Peptide
  • Endothelin receptor