ChemicalBook > CAS DataBase List > 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE

2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE

Product Name
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
CAS No.
65836-72-8
Chemical Name
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
Synonyms
DKM 2-93;Brn 2857211;CHEMBRDG-BB 9070724;N-(Dimethoxy-3,4 benzyl)-chloroacetamide;2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE;N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french];2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide;2-chloro-N-[(3,4-dimethoxyphenyl)methyl]ethanamide;Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-;2-chloro-N-(3,4-dimethoxybenzyl)acetamide(SALTDATA: FREE)
CBNumber
CB9796621
Molecular Formula
C11H14ClNO3
Formula Weight
243.69
MOL File
65836-72-8.mol
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2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Property

Melting point:
116-118 °C(Solv: carbon tetrachloride (56-23-5))
Boiling point:
425.7±45.0 °C(Predicted)
Density 
1.194±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 150 mg/mL (615.54 mM)
form 
Solid
pka
13.42±0.46(Predicted)
color 
White to light yellow
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-6514
Product name
DKM2-93
Purity
98.76%
Packaging
100mg
Price
$84
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC114033
Product name
2-Chloro-N-(3,4-dimethoxybenzyl)acetamide
Packaging
250mg
Price
$85
Updated
2021/12/16
Matrix Scientific
Product number
029584
Product name
2-Chloro-N-(3,4-dimethoxybenzyl)acetamide
Packaging
500mg
Price
$95
Updated
2021/12/16
ChemScene
Product number
CS-6514
Product name
DKM2-93
Purity
98.76%
Packaging
200mg
Price
$144
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC114033
Product name
2-Chloro-N-(3,4-dimethoxybenzyl)acetamide
Packaging
500mg
Price
$150
Updated
2021/12/16
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2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Chemical Properties,Usage,Production

Biological Activity

DKM 2-93 is a relatively selective UBA5 inhibitor with IC50 value of 430 μM.

in vitro

Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC 50 s of 90 and 30 μM, respectively.

in vivo

DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.

target

IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells)

2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE Suppliers

China 56 Ukraine 1 United Kingdom 1 United States 7 Global 65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
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32161
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InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
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58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
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58
MedChemExpress
Tel
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Fax
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
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Matrix Scientific
Tel
--
Fax
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Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
ChemBridge Corporation
Tel
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Fax
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Email
resupply@chembridge.com
Country
United States
ProdList
6648
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70

65836-72-8, 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDERelated Search:

2-CHLORO-N-[1-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)ETHYL]ACETAMIDE 1-(CHLOROACETYL)-2-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)PYRROLIDINE 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE 2-CHLORO-N-[1-(3,4-DIPROPOXYPHENYL)ETHYL]ACETAMIDE 2-CHLORO-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLMETHYL)-N-ETHYLACETAMIDE 2-(CHLOROACETYL)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE 1-(CHLOROACETYL)-5-(3,4-DIMETHOXYPHENYL)-3-THIEN-2-YL-4,5-DIHYDRO-1H-PYRAZOLE 1-(CHLOROACETYL)-2-(3,4-DIHYDRO-2H-1,5-BENZODIOXEPIN-7-YL)PYRROLIDINE 2-CHLORO-1-[1-(3,4-DIETHOXY-BENZYL)-6,7-DIETHOXY-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL]-ETHANONE 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)PROPANAMIDE 2-CHLORO-N-[1-(3,4-DIHYDRO-2H-1,5-BENZODIOXEPIN-7-YL)-2-METHYLPROPYL]ACETAMIDE 2-CHLORO-N-[4-(DIFLUOROMETHOXY)-3-METHOXYBENZYL]-N-METHYLACETAMIDE 2-CHLORO-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLMETHYL)-N-METHYLACETAMIDE 2-CHLORO-N-(5,6-DIMETHOXY-3-OXO-INDAN-1-YL)-ACETAMIDE 2-CHLORO-N-METHYL-N-(2,3,4-TRIMETHOXYBENZYL)ACETAMIDE 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)-N-METHYLACETAMIDE 2-CHLORO-1-(6,7-DIMETHOXY-1-PHENYL-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-ETHANONE N-[4-(BENZYLOXY)-3-METHOXYBENZYL]-2-CHLOROACETAMIDE

  • 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
  • CHEMBRDG-BB 9070724
  • 2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide
  • Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-
  • Brn 2857211
  • N-(Dimethoxy-3,4 benzyl)-chloroacetamide
  • N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french]
  • 2-chloro-N-(3,4-dimethoxybenzyl)acetamide(SALTDATA: FREE)
  • 2-chloro-N-[(3,4-dimethoxyphenyl)methyl]ethanamide
  • DKM 2-93
  • E1 activating enzyme,Ubiquitin activating enzyme,E1/E2/E3 Enzyme,Inhibitor,DKM 2-93,Ubiquitin conjugating enzyme,Ubiquitin ligase,inhibit,E3 ligating enzyme,E2 conjugating enzyme,DKM 293,DKM 2 93
  • 65836-72-8