Benufutamab
- Product Name
- Benufutamab
- CAS No.
- 2109730-69-8
- Chemical Name
- Benufutamab
- Synonyms
- Benufutamab;Research Grade Benufutamab;Benufutamab (anti-TNFRSF10B);Research Grade Benufutamab (DHA29101)
- CBNumber
- CB98081165
- Formula Weight
- 0
- MOL File
- Mol file
Benufutamab Property
- form
- Liquid
- color
- Colorless to light yellow
Benufutamab Chemical Properties,Usage,Production
Uses
Benufutamab (GEN1029) is a death receptor 5 (DR5)-specific agonistic antibody. Benufutamab is a mixture of 2 noncompeting DR5-specific IgG1 antibodies, each with an E430G mutation in the Fc domain. Benufutamab has antitumor effects[1].
in vivo
Benufutamab (GEN1029; HexaBody-DR5/DR5; 0.5-2 mg/kg; i.p.; once a week; for 9 weeks) shows significant antitumor activity in PDX models for colorectal cancer[2].
| Animal Model: | Balb/c athymic nude or NU/NU nude mice injected with colorectal cancer (CRC) cells[2] |
| Dosage: | 0.5 mg/kg, or 2 mg/kg |
| Administration: | i.p.; once a week; for 9 weeks |
| Result: | Showed significant antitumor activity. |
References
[1] Hilma J van der Horst, et al. Potent preclinical activity of HexaBody-DR5/DR5 in relapsed and/or refractory multiple myeloma. Blood Adv. 2021 Apr 27;5(8):2165-2172. DOI:10.1182/bloodadvances.2020003731
[2] Marije B Overdijk, et al. Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism. Mol Cancer Ther. 2020 Oct;19(10):2126-2138. DOI:10.1158/1535-7163.MCT-20-0044
Benufutamab Preparation Products And Raw materials
Raw materials
Preparation Products
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