Talquetamab
- Product Name
- Talquetamab
- CAS No.
- 2226212-40-2
- Chemical Name
- Talquetamab
- Synonyms
- Talquetamab;JNJ-64407564|||JNJ-7564;Talquetamab (anti-GPRC5D);Research Grade Talquetamab;Research Grade Talquetamab (DHK07701)
- CBNumber
- CB98132414
- Formula Weight
- 0
- MOL File
- Mol file
Talquetamab Property
- form
- Liquid
- color
- Colorless to light yellow
Talquetamab Chemical Properties,Usage,Production
Uses
Talquetamab (JNJ-64407564) is a humanized bispecific antibody that binds to GPRC5D (member of G protein-coupled receptor family C5 group D) and CD3 to induce T cell-mediated killing of GPRC5D-expressing MM cells through T cell recruitment and activation. Talquetamab (JNJ-64407564) has antitumor activity[1][2].
in vivo
Talquetamab (JNJ-64407564) (0.1-50 μg, s.c. or i.v.) has significant antitumor activity in H929 and MM mouse models[2].
| Animal Model: | Female NSG mice with H929 cells[2] |
| Dosage: | 0.1-10 μg (0.005 mg/kg) |
| Administration: | Subcutaneous injection; on days 0, 3, 5, 7, and 10 |
| Result: | Completely blocked tumor formation at 1 μg and 10 μg doses. |
| Animal Model: | Female NSG mice with human MM cells[2] |
| Dosage: | 0.1-50 μg (0.005 mg/kg) |
| Administration: | Intravenous injection; on days 15, 18, 22, 24, 29, 32, and 36 |
| Result: | Significantly inhibited tumor growth by 65% at the dose of 1μg and showed significant anti-tumor activity at 10 and 50 μg with complete tumor regression. |
References
[1] Christie P M Verkleij, et al. Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma. Blood Adv. 2021 Apr 27;5(8):2196-2215. DOI:10.1182/bloodadvances.2020003805
[2] Kodandaram Pillarisetti, et al. A T-cell-redirecting bispecific G-protein-coupled receptor class 5 member D x CD3 antibody to treat multiple myeloma. Blood. 2020 Apr 9;135(15):1232-1243. DOI:10.1182/blood.2019003342
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