5-BROMO-2-CARBOXY-3-METHYLPYRIDINE
- Product Name
- 5-BROMO-2-CARBOXY-3-METHYLPYRIDINE
- CAS No.
- 886365-43-1
- Chemical Name
- 5-BROMO-2-CARBOXY-3-METHYLPYRIDINE
- Synonyms
- 5-broMo-3-Methylpicolinic acid;5-BROMO-2-CARBOXY-3-METHYLPYRIDINE;5-BROMO-3-METHYLPICOLINIC ACID (TAX INVO;5-Bromo-3-methylpyridin-2-carboxylic acid;3-methyl-5-bromo-2-pyridinecarboxylic acid;5-bromo-3-methyl-2-pyridinecarboxylic acid;2-Pyridinecarboxylicacid, 5-broMo-3-Methyl-;5-BROMO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID;5-BROMO-2-CARBOXY-3-METHYLPYRIDINE ISO 9001：2015 REACH;5-Bromo-3-methylpicolinic acid, 5-Bromo-2-carboxy-3-methylpyridine
- CBNumber
- CB9817678
- Molecular Formula
- C7H6BrNO2
- Formula Weight
- 216.03
- MOL File
- 886365-43-1.mol
5-BROMO-2-CARBOXY-3-METHYLPYRIDINE Property
- Melting point:
- 161-163oC
- Boiling point:
- 330.5±42.0 °C(Predicted)
- Density
- 1.692±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 3.04±0.37(Predicted)
- form
- Powder
- color
- Off-white
Safety
- RIDADR
- UN2811
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B688140
- Product name
- 5-Bromo-3-methylpicolinicAcid
- Packaging
- 50g
- Price
- $615
- Updated
- 2021/12/16
- Product number
- 072959
- Product name
- 5-Bromo-2-carboxy-3-methylpyridine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- X1284
- Product name
- 5-Bromo-3-methylpicolinicacid
- Packaging
- 5g
- Price
- $26
- Updated
- 2021/12/16
- Product number
- OR61015
- Product name
- 5-Bromo-3-methylpyridine-2-carboxylicacid
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 4H21-9-X9
- Product name
- 5-Bromo-3-methylpyridine-2-carboxylic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $32
- Updated
- 2021/12/16
5-BROMO-2-CARBOXY-3-METHYLPYRIDINE Chemical Properties,Usage,Production
Uses
5-Bromo-3-methylpicolinic Acid is used to prepare oxazine derivatives as BACE inhibitors useful in treatment of neurological disorders.
Synthesis
156072-86-5
886365-43-1
Step B Synthesis of 5-bromo-3-methylpyridine-2-carboxylic acid: 5-bromo-3-methylpyridine-2-carbonitrile (3.9 g, 20 mmol) was dissolved in ethanol (30 mL), followed by the addition of 6.0 M aqueous sodium hydroxide solution (15 mL). The reaction mixture was stirred at 80 °C for 1.5 hours. Upon completion of the reaction, the reaction mixture was concentrated, diluted with water and extracted by partitioning with ethyl acetate (EtOAc). The aqueous phase was acidified to pH 2-3 with hydrochloric acid and the product was subsequently extracted with EtOAc. The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated to give the yellow solid product 5-bromo-3-methylpyridine-2-carboxylic acid (4.2 g, 98% yield).
References
[1] Patent: US2013/96144, 2013, A1. Location in patent: Paragraph 0390; 0391
[2] Patent: WO2008/100715, 2008, A1. Location in patent: Page/Page column 33-34
5-BROMO-2-CARBOXY-3-METHYLPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BROMO-2-CARBOXY-3-METHYLPYRIDINE manufacturers
- Product
- 5-BROMO-2-CARBOXY-3-METHYLPYRIDINE 886365-43-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-03
- Product
- 5-BROMO-2-CARBOXY-3-METHYLPYRIDINE 886365-43-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
- Product
- 5-BROMO-2-CARBOXY-3-METHYLPYRIDINE 886365-43-1
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08