1H-Imidazol-1-ylacetonitrile

Product Name: 1H-Imidazol-1-ylacetonitrile
CAS No.: 98873-55-3
Chemical Name: 1H-Imidazol-1-ylacetonitrile
Synonyms: CjHsN3;1-Imidazolylacetonitrile;1-(Cyanomethyl)imidazole;Luliconazole Impurity 25;IMidazal-1-yl-acetonitrile;IMIDAZOL-1-YL-ACETONITRILE;Luliconazole Intermediates;1H-imidazole-1-acetonitril;1H-imidazole-1-acetonitrile;Imidazole-1-yl-acetonitrile
CBNumber: CB9843699
Molecular Formula: C5H5N3
Formula Weight: 107.11
MOL File: 98873-55-3.mol

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1H-Imidazol-1-ylacetonitrile Property

Melting point:: 54.0 to 58.0 °C
Boiling point:: 116-120 °C(Press: 0.35 Torr)
Density: 1.11±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 5.63±0.10(Predicted)
form: Solid
color: White to Light yellow
InChI: InChI=1S/C5H5N3/c6-1-3-8-4-2-7-5-8/h2,4-5H,3H2
InChIKey: ZPGCVVBPGQJSPX-UHFFFAOYSA-N
SMILES: C1N(CC#N)C=CN=1

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Safety

RIDADR: UN 3439 6.1/PG III
HS Code: 2933.29.4300
HazardClass: IRRITANT
HazardClass: 6.1
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: I0990
Product name: (1-Imidazolyl)acetonitrile
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $140
Updated: 2025/07/31

TCI Chemical

Product number: I0990
Product name: (1-Imidazolyl)acetonitrile
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $416
Updated: 2025/07/31

TRC

Product number: I385620
Product name: 2-(1H-Imidazol-1-yl)acetonitrile
Packaging: 1g
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: J56690
Product name: 2-(1-Imidazolyl)acetonitrile
Packaging: 1g
Price: $27
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 96056
Product name: 2-(1H-Imidazol-1-yl)acetonitrile
Packaging: 500mg
Price: $425
Updated: 2021/12/16

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1H-Imidazol-1-ylacetonitrile Chemical Properties,Usage,Production

Uses

2-(1H-Imidazol-1-yl)acetonitrile is a reactant that has been used in the synthesis of lanoconazole (L174500), an antifungal.

Synthesis

288-32-4

590-17-0

98873-55-3

To a tetrahydrofuran (THF) solution of 1H-imidazole (5 g, 73.5 mmol) was added sodium hydride (1.8 g, 45 mmol) in batches and stirred at room temperature for 30 minutes. Subsequently, bromoacetonitrile (8.8 g, 73.9 mmol) was slowly added dropwise and stirring was continued for 2 hours at room temperature. Upon completion of the reaction, the reaction was quenched by the addition of water (50 mL) and saturated ammonium chloride solution (50 mL). The reaction mixture was extracted with ethyl acetate (100 mL x 3) and the organic layers were combined. The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=10:1) to give 2-(1H-imidazol-1-yl)acetonitrile (4.6 g, 59% yield) as a yellow oil.LRMS m/z: 108 [M+H]+.

References

[1] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 9, p. 3185 - 3198
[2] European Journal of Organic Chemistry, 2018, vol. 2018, # 18, p. 2110 - 2116
[3] New Journal of Chemistry, 2002, vol. 26, # 7, p. 926 - 932
[4] Patent: US2015/65522, 2015, A1. Location in patent: Paragraph 0469; 0470; 0471
[5] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 2009 - 2016

1H-Imidazol-1-ylacetonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Imidazol-1-ylacetonitrile Suppliers

Americas 1 Austria 1 China 175 Europe 1 Finland 1 France 1 Germany 1 India 27 Japan 1 Russia 1 Slovakia 1 Switzerland 1 United Kingdom 2 United States 19 Global 233

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View Lastest Price from 1H-Imidazol-1-ylacetonitrile manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-(Cyanomethyl)imidazole 98873-55-3
Price: US $1.10-9.90/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-18

Shaanxi Dideu New Materials Co. Ltd

Product: 1H-Imidazol-1-ylacetonitrile 98873-55-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 10000KGS
Release date: 2025-02-18

LY Global chemicals co.,ltd .

Product: 1H-Imidazol-1-ylacetonitrile 98873-55-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98.0%
Supply Ability: 10000kg
Release date: 2023-03-29

98873-55-3, 1H-Imidazol-1-ylacetonitrileRelated Search:

Methyl 4-imidazolecarboxylate Ethyl imidazole-4-carboxylate Dimethyl 4,5-imidazoledicarboxylate Imidazo[1,5-a]pyridine IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID 1H-Imidazole-2-carboxylic acid 1H-Imidazol-1-ylacetonitrile Lanoconazole Luliconazole 1,3-Bis(cyanomethyl)imidazolium bis(trifluoromethylsulfonyl)imide 1,3-Bis(cyanomethyl)imidazolium chloride 1-(Cyanomethyl)-3-methylimidazolium chloride 2-(4,5-DICHLORO-1H-IMIDAZOL-1-YL)ACETONITRILE 2-[2-(TRIFLUOROMETHYL)-1H-1,3-BENZIMIDAZOL-1-YL]ACETONITRILE CBI-BB ZERO/005479 AKOS BBS-00000213 (2-methyl-1H-benzimidazol-1-yl)acetonitrile SALOR-INT L299758-1EA

1-Imidazolylacetonitrile (1-(Cyanomethyl) imidazole)

1-(Cyanomethyl)imidazole

1-Imidazolylacetonitrile

IMIDAZOL-1-YL-ACETONITRILE

1H-imidazole-1-acetonitrile

2-(1-IMidazolyl)acetonitrile

1H-imidazol-1-ylacetonitrile(SALTDATA: FREE)

IMidazal-1-yl-acetonitrile

Imidazole-1-yl-acetonitrile

Imidazole-1-yl-acetonitrile(1-cyanomethyl)imidazole

2-(1H Imidazole -1-yl) acetonitrile

Luliconazole Intermediates

1H-imidazole-1-acetonitril

1H-Imidazole-1-yl acetonitrile

1H-IMIDAZOL-1-YLACETONITRILE

CjHsN3

Luliconazole Impurity 25

98873-55-3