6-Chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxanine-8-carboxylic acid
- Product Name
- 6-Chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxanine-8-carboxylic acid
- CAS No.
- 123040-79-9
- Chemical Name
- 6-Chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxanine-8-carboxylic acid
- Synonyms
- Azasetron Impurity;Azasetron Impurity 1;Azasetron Impurity 17;Azasetron InterMediate;6-Chloro-3,4-dihydro-4-methyl-;2H-1,4-BENZOXANINE-8-CARBOXYLICACID-6-CHLORO-3,4-DIHYD;6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxylic acid;6-Chloro-3,4-dihydro-4-methyl-3-oxo-2h-1,4-benzoxazine-8-aarboxylicacid;2H-1,4-BENZOXANINE-8-CARBOXYLICACID-6-CHLORO-3,4-DIHYDRO-4-METHYL-3-OXO-;6-CHLORO-3,4-DIHYDRO-4-METHYL-3-OXO-2H-1,4-BENZOXAZINE-8-CARBOXYLIC ACID
- CBNumber
- CB9844595
- Molecular Formula
- C10H8ClNO4
- Formula Weight
- 241.63
- MOL File
- 123040-79-9.mol
6-Chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxanine-8-carboxylic acid Property
- Melting point:
- 241-243°C
- Boiling point:
- 556.0±50.0 °C(Predicted)
- Density
- 1.516
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.70±0.20(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C10H8ClNO4/c1-12-7-3-5(11)2-6(10(14)15)9(7)16-4-8(12)13/h2-3H,4H2,1H3,(H,14,15)
- InChIKey
- ZTIKBJABRWRXFK-UHFFFAOYSA-N
- SMILES
- O1C2=C(C(O)=O)C=C(Cl)C=C2N(C)C(=O)C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- C382285
- Product name
- 6-Chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxanine-8-carboxylicAcid
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- J11255
- Product name
- AzasetronImpurity1
- Packaging
- 5mg
- Price
- $19.8
- Updated
- 2021/12/16
- Product number
- J11255
- Product name
- AzasetronImpurity1
- Packaging
- 25mg
- Price
- $39
- Updated
- 2021/12/16
- Product number
- FC149421
- Product name
- 6-Chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxanine-8-carboxylicacid
- Packaging
- 250mg
- Price
- $52.5
- Updated
- 2021/12/16
- Product number
- O161
- Product name
- 6-Chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxanine-8-carboxylicacid
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
6-Chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxanine-8-carboxylic acid Chemical Properties,Usage,Production
Synthesis
141761-83-3
123040-79-9
In a 500 mL three-necked flask, 150 mL of deionized water and 12 g (0.3 mol) of sodium hydroxide were added sequentially and stirred until the solid was completely dissolved. Subsequently, 100 mL of ethanol was added and the reaction system was cooled down to 20 °C. Under stirring, methyl 6-chloro-4-methyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-8-carboxylate (0.1 mol) was slowly added and the reaction was continued with stirring for 3 hours. After completion of the reaction, the reaction mixture was cooled to below 10 °C and the pH was adjusted with dilute hydrochloric acid to 2. The precipitated solid was collected by filtration and dried to afford 6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylic acid as an off-white solid with a yield of 21.9 g and 91% yield.
References
[1] Patent: CN104557907, 2016, B. Location in patent: Paragraph 0015; 0079; 0080
[2] Patent: CN103351386, 2016, B. Location in patent: Paragraph 0015; 0028; 0029
[3] Chemical and Pharmaceutical Bulletin, 1992, vol. 40, # 3, p. 624 - 630
6-Chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxanine-8-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxanine-8-carboxylic acid manufacturers
- Product
- Azasetron Impurity 123040-79-9
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98
- Supply Ability
- 10000000
- Release date
- 2025-02-19
- Product
- 6-Chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxanine-8-carboxylic acid 123040-79-9
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-08