ChemicalBook > CAS DataBase List > 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT
4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT
- Product Name
- 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT
- CAS No.
- 153436-22-7
- Chemical Name
- 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT
- Synonyms
- GAVESTINEL;1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-;4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT;4,6-Dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
- CBNumber
- CB9845365
- Molecular Formula
- C18H12Cl2N2O3
- Formula Weight
- 375.21
- MOL File
- 153436-22-7.mol
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4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Property
- Melting point:
- >270°C (dec.)
- Boiling point:
- 701.1±60.0 °C(Predicted)
- Density
- 1.561±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at RT
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 3.77±0.30(Predicted)
- form
- Solid
- color
- Pale Yellow
- Stability:
- Hygroscopic
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N-Bromosuccinimide Price
Tocris
- Product number
- 2348
- Product name
- Gavestinel
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $183
- Updated
- 2021/12/16
Tocris
- Product number
- 2348
- Product name
- Gavestinel
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $771
- Updated
- 2021/12/16
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4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Chemical Properties,Usage,Production
Uses
Treatment of stroke (N-methylD-aspartate NMDA receptor antagonist).
Definition
ChEBI: 3-(3-anilino-3-oxoprop-1-enyl)-4,6-dichloro-1H-indole-2-carboxylic acid is an indolyl carboxylic acid.
Biological Activity
Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (K d = 0.8 nM). Displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Orally bioavailable and active in vivo .
Safety Profile
A poison by intravenous route. When heated to decomposition it emits toxic vapors of NOx and Cl-.
4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
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4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Suppliers
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153436-22-7, 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALTRelated Search:
4-CHLORO-1H-INDOLE-2-CARBALDEHYDE
6-CHLORO-2-METHYLINDOLE
6-CHLORO-1H-INDOLE-2-CARBALDEHYDE
4-chloro-1H-indole-2-carboxylic acid
6-Chloroindole-2-carboxylic acid
4,6-DICHLORO-2-METHYLINDOLE
4-CHLORO-2-METHYL-1H-INDOLE
(6-CHLORO-1H-INDOL-2-YL)-METHANOL
4,6-Dichloro-1H-indole-2-carboxylic acid
4,6-Dichloro-1H-indole
4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT