4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT

Product Name: 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT
CAS No.: 153436-22-7
Chemical Name: 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT
Synonyms: GAVESTINEL;1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-;4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT;4,6-Dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
CBNumber: CB9845365
Molecular Formula: C18H12Cl2N2O3
Formula Weight: 375.21
MOL File: 153436-22-7.mol

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4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Property

Melting point:: >270°C (dec.)
Boiling point:: 701.1±60.0 °C(Predicted)
Density: 1.561±0.06 g/cm3(Predicted)
storage temp.: Desiccate at RT
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 3.77±0.30(Predicted)
form: Solid
color: Pale Yellow
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 2348
Product name: Gavestinel
Purity: ≥98%(HPLC)
Packaging: 10
Price: $183
Updated: 2021/12/16

Tocris

Product number: 2348
Product name: Gavestinel
Purity: ≥98%(HPLC)
Packaging: 50
Price: $771
Updated: 2021/12/16

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4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Chemical Properties,Usage,Production

Uses

Treatment of stroke (N-methylD-aspartate NMDA receptor antagonist).

Definition

ChEBI: 3-(3-anilino-3-oxoprop-1-enyl)-4,6-dichloro-1H-indole-2-carboxylic acid is an indolyl carboxylic acid.

Biological Activity

Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (K d = 0.8 nM). Displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Orally bioavailable and active in vivo .

Safety Profile

A poison by intravenous route. When heated to decomposition it emits toxic vapors of NOx and Cl-.

4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Suppliers

China 9 Germany 1 United Kingdom 1 United States 3 Global 14

3B Pharmachem (Wuhan) International Co.,Ltd.

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Country: China
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EMMX Biotechnology LLC

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Beijing Boorsen Biotechnology Co., Ltd

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Guangzhou Squirrel Biotechnology Co., Ltd.

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Guangzhou Junuo Biotechnology Co., Ltd.

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Chongqing Boer Biotechnology Co., Ltd.

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153436-22-7, 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALTRelated Search:

4-chloro-1H-indole-2-carboxylic acid 4-CHLORO-1H-INDOLE-2-CARBALDEHYDE 6-CHLORO-2-METHYLINDOLE 6-CHLORO-1H-INDOLE-2-CARBALDEHYDE 6-Chloroindole-2-carboxylic acid 4,6-DICHLORO-2-METHYLINDOLE 4-CHLORO-2-METHYL-1H-INDOLE (6-CHLORO-1H-INDOL-2-YL)-METHANOL 4,6-Dichloro-1H-indole-2-carboxylic acid 4,6-Dichloro-1H-indole 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT

GAVESTINEL

4,6-Dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt

4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT

1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-

153436-22-7

C18H12Cl2N2O3

C18H11Cl2N2O3Na