ChemicalBook > CAS DataBase List > 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT

4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT

Product Name
4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT
CAS No.
153436-22-7
Chemical Name
4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT
Synonyms
GAVESTINEL;1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-;4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT;4,6-Dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
CBNumber
CB9845365
Molecular Formula
C18H12Cl2N2O3
Formula Weight
375.21
MOL File
153436-22-7.mol
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4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Property

Melting point:
>270°C (dec.)
Boiling point:
701.1±60.0 °C(Predicted)
Density 
1.561±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at RT
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
3.77±0.30(Predicted)
form 
Solid
color 
Pale Yellow
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
2348
Product name
Gavestinel
Purity
≥98%(HPLC)
Packaging
10
Price
$183
Updated
2021/12/16
Tocris
Product number
2348
Product name
Gavestinel
Purity
≥98%(HPLC)
Packaging
50
Price
$771
Updated
2021/12/16
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4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Chemical Properties,Usage,Production

Uses

Treatment of stroke (N-methylD-aspartate NMDA receptor antagonist).

Definition

ChEBI: 3-(3-anilino-3-oxoprop-1-enyl)-4,6-dichloro-1H-indole-2-carboxylic acid is an indolyl carboxylic acid.

Biological Activity

Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (K d = 0.8 nM). Displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Orally bioavailable and active in vivo .

Safety Profile

A poison by intravenous route. When heated to decomposition it emits toxic vapors of NOx and Cl-.

4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4512
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Suzhou Chenrui Biotechnology Co. LTD
Tel
17625585511
Fax
qq:1580084073
Email
1580084073@qq.com
Country
China
ProdList
615
Advantage
58

153436-22-7, 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALTRelated Search:


  • GAVESTINEL
  • 4,6-Dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
  • 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT
  • 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-
  • 153436-22-7
  • C18H12Cl2N2O3
  • C18H11Cl2N2O3Na