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(6-CHLORO-1H-INDOL-2-YL)-METHANOL

Product Name
(6-CHLORO-1H-INDOL-2-YL)-METHANOL
CAS No.
53590-58-2
Chemical Name
(6-CHLORO-1H-INDOL-2-YL)-METHANOL
Synonyms
1H-Indole-2-methanol, 6-chloro-;(6-CHLORO-1H-INDOL-2-YL)-METHANOL
CBNumber
CB02460372
Molecular Formula
C9H8ClNO
Formula Weight
181.62
MOL File
53590-58-2.mol
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(6-CHLORO-1H-INDOL-2-YL)-METHANOL Property

storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Frontier Specialty Chemicals
Product number
JK109649
Product name
(6-Chloro-1H-indol-2-yl)methanol
Purity
98%
Packaging
1g
Price
$287
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0050755
Product name
(6-CHLORO-1H-INDOL-2-YL)METHANOL
Purity
95.00%
Packaging
1G
Price
$703.4
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0050755
Product name
(6-CHLORO-1H-INDOL-2-YL)METHANOL
Purity
95.00%
Packaging
5G
Price
$1155.76
Updated
2021/12/16
Ambeed
Product number
A287186
Product name
(6-Chloro-1H-indol-2-yl)methanol
Purity
97%
Packaging
100mg
Price
$58
Updated
2021/12/16
Ambeed
Product number
A287186
Product name
(6-Chloro-1H-indol-2-yl)methanol
Purity
97%
Packaging
250mg
Price
$87
Updated
2021/12/16
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(6-CHLORO-1H-INDOL-2-YL)-METHANOL Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Synthesis

27034-51-1

53590-58-2

General procedure for the synthesis of 2-hydroxymethyl-6-chloroindole from ethyl 6-chloroindole-2-carboxylate: 2.00 g (8.94 mmol) of ethyl 6-chloroindole-2-carboxylate was dissolved in 50 ml of ethyl ether at 0°C, and 0.475 g (12.5 mmol) of lithium aluminum hydride was added slowly. The reaction mixture was heated to 45°C to reflux the reaction. Upon completion of the reaction, 10 ml of water, 10 ml of 2M aqueous sodium hydroxide solution and 10 ml of water were added sequentially at 0°C to quench the reaction. The aqueous layer was separated and extracted with tert-butyl methyl ether (3 x 100 ml). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product 2-hydroxymethyl-6-chloroindole (1.64 g; 100% yield) as a white solid. MS data: MS m/e (relative abundance): 180 ([M-H]+, 100).

References

[1] Patent: US2007/27173, 2007, A1. Location in patent: Page/Page column 112
[2] Patent: US2008/161315, 2008, A1. Location in patent: Page/Page column 15
[3] Patent: US2007/27163, 2007, A1. Location in patent: Page/Page column 22
[4] Journal of Medicinal Chemistry, 2007, vol. 50, # 6, p. 1380 - 1400
[5] Patent: US2003/144282, 2003, A1

(6-CHLORO-1H-INDOL-2-YL)-METHANOL Preparation Products And Raw materials

Raw materials

Ethanol Diethyl oxalate Tetrahydrofuran Diethyl ether Lithium Aluminum Hydride Hydrochloric acid Acetic acid Potassium 4-Chloro-2-nitrotoluene

Preparation Products

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(6-CHLORO-1H-INDOL-2-YL)-METHANOL Suppliers

China 22 India 1 United States 4 Global 27
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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sales@tcaschem.com
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66028182 18626450290
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Amadis Chemical Company Limited
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0086-571-89925065
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Shanghai Anmike Chemical Co. Ltd.
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Hunan chemfish Scientific co.,ltd
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53590-58-2, (6-CHLORO-1H-INDOL-2-YL)-METHANOLRelated Search:

Ethyl 4,6-dichloroindole-2-carboxylate 6-Chloroindole-2-carboxylic acid ethyl ester 6-Chloroindole-2-carboxylic acid 6-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER 4,6-Dichloro-1H-indole-2-carboxylic acid 4,6-DICHLORO-3-[(1E)-3-OXO-3-(PHENYLAMINO)-1-PROPENYL]-1H-INDOLE-2-CARBOXYLIC ACID SODIUM SALT ETHYL 4,6-DICHLORO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE ALPHA-PHENYL-1-(2-PHENYLETHYL)-4-PIPERIDINEMETHANOL ETHYL 3-(2-CARBOXY-VINYL)-4,6-DICHLORO-1H-INDOLE-2-CARBOXYLATE (Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE 6,7-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID 6-CHLORO-7-METHYL-1H-INDOLE-2-CARBOXYLIC ACID 6-CHLORO-4-FLUORO-1H-INDOLE-2-CARBOXYLIC ACID 6,7-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER 1H-INDOLE-2-CARBOXYLIC ACID,6-CHLORO-4-FLUORO-3-FORMYL-,ETHYL ESTER RARECHEM AL BF 1257 4,6-DICHLORO-3-HYDROXYMETHYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER 1-(beta-Dimethylaminoaethyl)-2-ethoxycarbonyl-3-ethoxy-6-chlor-indol-t oluol-4-sulfonat

  • (6-CHLORO-1H-INDOL-2-YL)-METHANOL
  • 1H-Indole-2-methanol, 6-chloro-
  • 53590-58-2