(6-CHLORO-1H-INDOL-2-YL)-METHANOL
- Product Name
- (6-CHLORO-1H-INDOL-2-YL)-METHANOL
- CAS No.
- 53590-58-2
- Chemical Name
- (6-CHLORO-1H-INDOL-2-YL)-METHANOL
- Synonyms
- 1H-Indole-2-methanol, 6-chloro-;(6-CHLORO-1H-INDOL-2-YL)-METHANOL
- CBNumber
- CB02460372
- Molecular Formula
- C9H8ClNO
- Formula Weight
- 181.62
- MOL File
- 53590-58-2.mol
(6-CHLORO-1H-INDOL-2-YL)-METHANOL Property
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- JK109649
- Product name
- (6-Chloro-1H-indol-2-yl)methanol
- Purity
- 98%
- Packaging
- 1g
- Price
- $287
- Updated
- 2021/12/16
- Product number
- HCH0050755
- Product name
- (6-CHLORO-1H-INDOL-2-YL)METHANOL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $703.4
- Updated
- 2021/12/16
- Product number
- HCH0050755
- Product name
- (6-CHLORO-1H-INDOL-2-YL)METHANOL
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1155.76
- Updated
- 2021/12/16
- Product number
- A287186
- Product name
- (6-Chloro-1H-indol-2-yl)methanol
- Purity
- 97%
- Packaging
- 100mg
- Price
- $58
- Updated
- 2021/12/16
- Product number
- A287186
- Product name
- (6-Chloro-1H-indol-2-yl)methanol
- Purity
- 97%
- Packaging
- 250mg
- Price
- $87
- Updated
- 2021/12/16
(6-CHLORO-1H-INDOL-2-YL)-METHANOL Chemical Properties,Usage,Production
Chemical Properties
Light yellow solid
Synthesis
27034-51-1
53590-58-2
General procedure for the synthesis of 2-hydroxymethyl-6-chloroindole from ethyl 6-chloroindole-2-carboxylate: 2.00 g (8.94 mmol) of ethyl 6-chloroindole-2-carboxylate was dissolved in 50 ml of ethyl ether at 0°C, and 0.475 g (12.5 mmol) of lithium aluminum hydride was added slowly. The reaction mixture was heated to 45°C to reflux the reaction. Upon completion of the reaction, 10 ml of water, 10 ml of 2M aqueous sodium hydroxide solution and 10 ml of water were added sequentially at 0°C to quench the reaction. The aqueous layer was separated and extracted with tert-butyl methyl ether (3 x 100 ml). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product 2-hydroxymethyl-6-chloroindole (1.64 g; 100% yield) as a white solid. MS data: MS m/e (relative abundance): 180 ([M-H]+, 100).
References
[1] Patent: US2007/27173, 2007, A1. Location in patent: Page/Page column 112
[2] Patent: US2008/161315, 2008, A1. Location in patent: Page/Page column 15
[3] Patent: US2007/27163, 2007, A1. Location in patent: Page/Page column 22
[4] Journal of Medicinal Chemistry, 2007, vol. 50, # 6, p. 1380 - 1400
[5] Patent: US2003/144282, 2003, A1
(6-CHLORO-1H-INDOL-2-YL)-METHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
(6-CHLORO-1H-INDOL-2-YL)-METHANOL Suppliers
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- Country
- India
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