6-CHLORO-2-METHYLINDOLE
- Product Name
- 6-CHLORO-2-METHYLINDOLE
- CAS No.
- 6127-17-9
- Chemical Name
- 6-CHLORO-2-METHYLINDOLE
- Synonyms
- 6-CHLORO-2-METHYLINDOLE;6-Chloro-2-methyl-1H-indole;1H-Indole, 6-chloro-2-Methyl-;6-Chloro-2-methyl-1H-indole 98%;（97％）6-Chloro-2-methyl-1H-indole;6-Chloro-2-methyl-1H-indole
- CBNumber
- CB0501613
- Molecular Formula
- C9H8ClN
- Formula Weight
- 165.62
- MOL File
- 6127-17-9.mol
6-CHLORO-2-METHYLINDOLE Property
- Melting point:
- 75-77
- Boiling point:
- 302.7±22.0 °C(Predicted)
- Density
- 1.273±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 16.67±0.30(Predicted)
- Appearance
- White to off-white Solid
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 3H31-5-38
- Product name
- 6-Chloro-2-methyl-1H-indole
- Packaging
- 100mg
- Price
- $122
- Updated
- 2021/12/16
- Product number
- FC142134
- Product name
- 6-Chloro-2-methylindole
- Packaging
- 50mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- Y9616
- Product name
- 6-Chloro-2-methyl-1H-indole
- Packaging
- 100mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- 3H31-5-38
- Product name
- 6-Chloro-2-methyl-1H-indole
- Packaging
- 250mg
- Price
- $194
- Updated
- 2021/12/16
- Product number
- FC142134
- Product name
- 6-Chloro-2-methylindole
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
6-CHLORO-2-METHYLINDOLE Chemical Properties,Usage,Production
Uses
6-CHLORO-2-METHYLINDOLE is commonly used in the synthesis of small molecule drugs.
Synthesis
163688-23-1
6127-17-9
Compound 5 (2.3 g, 8.12 mmol) was dissolved in dichloromethane (40 mL) under the protection of inert atmosphere and trifluoroacetic acid (7.5 mL) was slowly added under stirring at room temperature. The reaction mixture was stirred continuously at room temperature for 2 h. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction was quenched with deionized water (40 mL) and subsequently extracted with dichloromethane (2 x 50 mL). The organic phases were combined, washed sequentially with saturated sodium bicarbonate solution (40 mL) and saturated saline (40 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by recrystallization from 5% ethyl acetate/hexane mixed solvent to give compound 6 (1 g, 77% yield) as an off-white solid.1H NMR (500 MHz, DMSO-d6) δ: 11.02 (br s, 1H), 7.36 (d, J = 8.0 Hz, 1H), 7.25 (s, 1H), 6.90 (d, J = 8.5 Hz. 1H), 6.11 (s, 1H), 2.34 (s, 3H). Liquid chromatography-mass spectrometry (LC-MS) analysis showed a purity of 93.5% and a measured (M-H)- of 164 (column: XBridge C-18, 50×3.0 mm, 3.5 μm; mobile phase: 5 mM ammonium acetate/acetonitrile; flow rate: 0.8 mL/min).
References
[1] Patent: WO2015/48301, 2015, A1. Location in patent: Paragraph 00441
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 8, p. 2684 - 2690
6-CHLORO-2-METHYLINDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-CHLORO-2-METHYLINDOLE manufacturers
- Product
- 6-CHLORO-2-METHYLINDOLE 6127-17-9
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2019-12-25