2-BROMOQUINOLINE-4-CARBOXYLIC ACID
- Product Name
- 2-BROMOQUINOLINE-4-CARBOXYLIC ACID
- CAS No.
- 15733-87-6
- Chemical Name
- 2-BROMOQUINOLINE-4-CARBOXYLIC ACID
- Synonyms
- 2-BROMOQUINOLINE-4-CARBOXYLIC ACID;4-Quinolinecarboxylic acid, 2-bromo-
- CBNumber
- CB9845491
- Molecular Formula
- C10H6BrNO2
- Formula Weight
- 252.06
- MOL File
- 15733-87-6.mol
2-BROMOQUINOLINE-4-CARBOXYLIC ACID Property
- Melting point:
- 175-176 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 394.7±27.0 °C(Predicted)
- Density
- 1.732±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 2.17±0.10(Predicted)
- Appearance
- Off-white to gray Solid
- InChI
- InChI=1S/C10H6BrNO2/c11-9-5-7(10(13)14)6-3-1-2-4-8(6)12-9/h1-5H,(H,13,14)
- InChIKey
- LUHABDKNXNXNTO-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=CC=2)C(C(O)=O)=CC=1Br
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B695910
- Product name
- 2-Bromoquinoline-4-carboxylicacid
- Packaging
- 50mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- B695910
- Product name
- 2-Bromoquinoline-4-carboxylicacid
- Packaging
- 100mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- OR906018
- Product name
- 2-Bromoquinoline-4-carboxylicacid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $67
- Updated
- 2021/12/16
- Product number
- OR906018
- Product name
- 2-Bromoquinoline-4-carboxylicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $202
- Updated
- 2021/12/16
- Product number
- 073878
- Product name
- 2-Bromoquinoline-4-carboxylic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $231
- Updated
- 2021/12/16
2-BROMOQUINOLINE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
15733-89-8
15733-87-6
General procedure for the synthesis of 2-bromoquinoline-4-carboxylic acid from 2-quinolone-4-carboxylic acid: a mixture of 2-hydroxyquinoline-4-carboxylic acid (4.0 g, 21.2 mmol) and phosphorus tribromide (25.0 g, 87.2 mmol) in toluene (40 mL) was heated and refluxed for 3 hours at 100°C. Upon completion of the reaction, the mixture was cooled to room temperature and carefully poured into crushed ice. The mixture was extracted with ethyl acetate (2 x 250 mL), the organic phases were combined, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was dissolved in 1N sodium hydroxide solution (150 mL) and extracted with ethyl acetate (2 x 100 mL). The aqueous phase was adjusted to pH 3 with 1N hydrochloric acid and a white solid was precipitated. The solid was collected by filtration, washed with water and dried to give 2-bromoquinoline-4-carboxylic acid (3.0 g, 56% yield) as a white solid.
References
[1] Patent: WO2006/69063, 2006, A1. Location in patent: Page/Page column 98
[2] Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 23, p. 589
[3] Patent: EP2325181, 2011, A1. Location in patent: Page/Page column 61
2-BROMOQUINOLINE-4-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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