ChemicalBook > CAS DataBase List > Mildronate

Mildronate

Product Name
Mildronate
CAS No.
76144-81-5
Chemical Name
Mildronate
Synonyms
3-(2,2,2-triMethylhydraziniuM)propionate dehydrate;2-(2-Carboxyethyl)-1,1,1-trimethyl Hydrazinium Inner Salt;MET88;Quateri;Kvaterin;Quaterin;Mildrote;Mildonate;Meldomiun;MILDRONATE
CBNumber
CB9850590
Molecular Formula
C6H14N2O2
Formula Weight
146.19
MOL File
76144-81-5.mol
More
Less

Mildronate Property

Melting point:
85-900C
storage temp. 
Refrigerator
solubility 
Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
CAS DataBase Reference
76144-81-5(CAS DataBase Reference)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TRC
Product number
M344450
Product name
Mildronate
Packaging
100mg
Price
$140
Updated
2021/12/16
Matrix Scientific
Product number
139821
Product name
Mildronate
Purity
95%+
Packaging
1g
Price
$436
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0000658
Product name
MILDRONATE
Purity
95.00%
Packaging
100MG
Price
$525
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
12345
Product name
Mildronate
Packaging
250mg
Price
$590
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0000658
Product name
MILDRONATE
Purity
95.00%
Packaging
250MG
Price
$685
Updated
2021/12/16
More
Less

Mildronate Chemical Properties,Usage,Production

Description

Mildronate is a cardiac and neuroprotective drug. It is a compound with a new structure first developed by Latvia Institute of Organic Synthesis. It was first developed by Grindeks in the former Soviet Union in 1989. On the market, the drug is a structural analog of carnitine, which can compete with carnitine for γ-trimethylaminobutyrate hydroxylase, reduce the concentration of free carnitine and long-chain acetylcarnitine in cells, so it can inhibit Carnitine-dependent fatty acid oxidation. Meldonium was added to the WADA list of banned substances on January 1, 2016 because of "evidence of its use by athletes with the intention of enhancing performance."

Chemical Properties

White Crystalline Powder

Uses

Mildronate is a drug used to treat angina, myocardial infarction, and chronic heart failure. It is a novel pharmaceutical composition based on a reverse transcriptase inhibitor and meldonium.This compound generally contains a significant amount of water.

Definition

ChEBI: Mildronate is an ammonium betaine that is beta-alaninate in which one of the amino hydrogens is replaced by a trimethylamino group. A clinically used cardioprotective drug that is used for treatment of heart failure, myocardial infarction, arrhythmia, atherosclerosis and diabetes. It has a role as a cardioprotective agent, a neuroprotective agent and an EC 1.14.11.1 (gamma-butyrobetaine dioxygenase) inhibitor.

General Description

Mildronate (3-(2,2,2-trimethylhydrazinium)propionate; MET-88; meldonium, quaterine) is an antiischemic drug developed at the Latvian Institute of Organic Synthesis. Mildronate was designed to inhibit carnitine biosynthesis in order to prevent accumulation of cytotoxic intermediate products of fatty acida-oxidation in ischemic tissues and to block this highly oxygen-consuming process. Mildronate is efficient in the treatment of heart is chemia and its consequences. Extensive evaluation of pharmacological activities of mildronate revealed its beneficial effect on cerebral circulation disorders and central nervous system (CNS) functions. The drug is used in neurological clinics for the treatment of brain circulation disorders. It appears to improve patients’ mood; they become more active, their motor dysfunction decreases, and asthenia, dizziness and nausea become less pronounced. Since the brain does not utilize fatty acids as fuel other mechanisms of action of mildronate in CNS should be considered. Several reports indicate the possible existence of an alternative, non-carnitine dependent mechanism of action of mildronate. Our recent findings suggest that CNS effects of mildronate could be mediated by stimulation of the nitric oxide production in the vascular endothelium by modification of the ? butyrobetaine and its esters pools. It is hypothesized that mildronate may increase the formation of the ?-butyrobetaine esters. The latter are potent cholinomimetics and may activate eNOS via acetylcholine receptors or specific?-butyrobetaine ester receptors.

Pharmacology

Mildronate is efficient in the treatment of heart is chemia and its consequences. Extensive evaluation of pharmacological activities of mildronate revealed its beneficial effect on cerebral circulation disorders and central nervous system (CNS) functions. The drug is used in neurological clinics for the treatment of brain circulation disorders. It appears to improve patients’ mood; they become more active, their motor dysfunction decreases, and asthenia, dizziness and nausea become less pronounced. Since the brain does not utilize fatty acids as fuel other mechanisms of action of mildronate in CNS should be considered. Several reports indicate the possible existence of an alternative, non-carnitine dependent mechanism of action of mildronate. Our recent findings suggest that CNS effects of mildronate could be mediated by stimulation of the nitric oxide production in the vascular endothelium by modification of the ? butyrobetaine and its esters pools.

Side effects

Possible side effects of Mildronate treatment were an allergic reaction , weakness , headache , and discomfort in the epigastrium. According to the manufacturer of Mildronate GX, the commercial pharmaceutical product of meldonium, there are some rare adverse effects, including allergic reactions (redness and itchy skin, urticaria, rash, and/or angioedema), dyspepsia, tachycardia, and change (increase or decrease) in blood pressure.

Clinical claims and research

Mildronate (Grindeks, Latvia), an inhibitor of l-carnitine biosynthesis pathway via the inhibition of γ-butyrobetaine dioxygenase, is used for the treatment of myocardial ischemia in Eastern Europe and has shown a neuroprotective effect in several stroke models. Mildronate treatment improves functional recovery following middle cerebral artery occlusion in rats even though the infarct size did not decrease (Svalbe et al 2011). Analysis of cerebellar tissue extracts revealed significant decrease of concentration of l-carnitine and increase of γ-butyrobetaine. Russian studies have reported efficacy of the mildronate in treatment of patients with ischemic stroke. A randomized, double-blind, placebo-controlled phase II clinical trial in ischemic stroke patients is ongoing at the Xijing Hospital in China (ClinicalTrials. gov Identifier: NCT01800357).

Mode of action

Mildronate is a cardioprotective drug, the main mechanism of action of Mildronate is based on carnitine biosynthesis inhibition aimed to prevent accumulation of cytotoxic intermediate products of fatty acid beta-oxidation in ischemic tissues and to block this highly oxygen-consuming process.

Mildronate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Mildronate Suppliers

BIOSYNTH AG
Tel
--
Fax
--
Email
welcome@biosynth.ch
Country
Switzerland
ProdList
1308
Advantage
60
More
Less

View Lastest Price from Mildronate manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Mildronate 76144-81-5
Price
US $99.00-45.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-11-26
Sinoway Industrial co., ltd.
Product
Mildronate 76144-81-5
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
99% up /EP
Supply Ability
20 tons
Release date
2022-08-12
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Mildronate 76144-81-5
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min, injection
Supply Ability
100kg
Release date
2021-07-01

76144-81-5, MildronateRelated Search:


  • 3-(2,2,2-triMethylhydraziniuM)propionate dehydrate
  • Mildronate 3-(2,2,2-Trimethylhydrazine)propionate
  • 3-(trimethylammonioamino)propionate
  • 3-(trimethylazaniumylamino)propanoate
  • 3-(2,2,2-trimethyldiazan-2-iumyl)propanoate dihydrate
  • Kvaterin
  • 2-(2-carboxyethyl)-1,1,1-trimethylhydrazinium hydroxide inner salt
  • 3-(2,2,2-trimethylhydrazine)propionate
  • MILDRONATE
  • Mildonate
  • 3-(2,2,2-Trimethylhydrazinium)propionate
  • 2-(2-Carboxyethyl)-1,1,1-trimethyl Hydrazinium Inner Salt
  • Meldomiun
  • MET88
  • Quateri
  • 3-(trimethylammonioamino)propanoate
  • Quaterin
  • 1,1,1-Trimethylhydrazinium 2-propionate
  • 2-(2-Carboxylatoethyl)-1,1,1-trimethylhydrazinium
  • 3-[(Trimethylaminio)amino]propionic acidanion
  • N-Trimethyl-hydrazine-3-propionate
  • Mildronate,MeldoniuM
  • Mildronate API
  • Mildronate inject grade
  • Mildronate inject or Oral
  • Mildronate USP/EP/BP
  • Mildronate powder
  • MildronateQ: What is Mildronate Q: What is the CAS Number of Mildronate Q: What is the storage condition of Mildronate
  • Mildrote
  • 2H3]-Mildronate HCl
  • 76144-81-5
  • C6H18N2O4
  • Cardiovascular
  • Pharmaceutical intermediate
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Pharma raw material