1,3,4,9-TETRAHYDRO-B-CARBOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name: 1,3,4,9-TETRAHYDRO-B-CARBOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.: 168824-94-0
Chemical Name: 1,3,4,9-TETRAHYDRO-B-CARBOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms: 2-Boc-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole;tert-Butyl3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxyla;tert-Butyl 1,3,4,9-tetrahydro-2H-beta-carboline-2-carboxylate;tert-butyl 1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate;tert-butyl 3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate;1,3,4,9-TETRAHYDRO-B-CARBOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-Butyl 1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate;1,3,4,9-Tetrahydro-beta-carboline-2-carboxylic acid tert-butyl ester;2H-Pyrido[3,4-b]indole-2-carboxylic acid, 1,3,4,9-tetrahydro-, 1,1-dimethylethyl ester
CBNumber: CB9850787
Molecular Formula: C16H20N2O2
Formula Weight: 272.34
MOL File: 168824-94-0.mol

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1,3,4,9-TETRAHYDRO-B-CARBOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Melting point:: 151℃
storage temp.: 2-8°C
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0125108
Product name: 1,3,4,9-TETRAHYDRO-B-CARBOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $503.1
Updated: 2021/12/16

AK Scientific

Product number: 8627AA
Product name: tert-Butyl3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate
Packaging: 5g
Price: $628
Updated: 2021/12/16

SynChem

Product number: SC-26433
Product name: 1,3,4,9-Tetrahydro-b-carboline-2-carboxylic acid tert-butyl ester
Purity: 95+%
Packaging: 5G
Price: $1095
Updated: 2021/12/16

Ambeed

Product number: A664204
Product name: tert-Butyl3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate
Purity: 95+%
Packaging: 250mg
Price: $24
Updated: 2021/12/16

Ambeed

Product number: A664204
Product name: tert-Butyl3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate
Purity: 95+%
Packaging: 1g
Price: $52
Updated: 2021/12/16

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1,3,4,9-TETRAHYDRO-B-CARBOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

16502-01-5

24424-99-5

168824-94-0

The general procedure for the synthesis of tert-butyl 3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate (Intermediate B3) from 1,2,3,4-tetrahydro-9H-pyrido[3,4-B]indole (Intermediate A) and di-tert-butyl dicarbonate is as follows: 516 mg of Intermediate A was dissolved in dichloromethane (CH2Cl2), and di-tert-butyl dicarbonate was added. Butyl di-tert-butyl dicarbonate (Boc2O) was added and the reaction was stirred at room temperature for 9 hours. Upon completion of the reaction, the reaction mixture was diluted with 20 mL of dichloromethane, followed by extraction with purified water three times and washing with saturated saline once. The organic phase was collected, dried over anhydrous sodium sulfate and the solvent was removed by rotary evaporation. The resulting crude product was purified by silica gel column chromatography with the eluent of petroleum ether (PE)/ethyl acetate (EtOAc) = 4:1 (v/v), resulting in 665 mg of intermediate B3 in 81% yield.

References

[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 11, p. 2197 - 2206
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 2, p. 639 - 651
[3] Patent: CN106883230, 2017, A. Location in patent: Paragraph 0037
[4] Angewandte Chemie - International Edition, 2017, vol. 56, # 47, p. 14968 - 14972
[5] Angew. Chem., 2017, vol. 129, # 47, p. 15164 - 15168,5

1,3,4,9-TETRAHYDRO-B-CARBOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

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1,3,4,9-TETRAHYDRO-B-CARBOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

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168824-94-0, 1,3,4,9-TETRAHYDRO-B-CARBOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

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1,3,4,9-Tetrahydro-beta-carboline-2-carboxylic acid tert-butyl ester

tert-butyl 3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

1,3,4,9-TETRAHYDRO-B-CARBOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER

tert-Butyl 1,3,4,9-tetrahydro-2H-beta-carboline-2-carboxylate

tert-Butyl 1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate

tert-butyl 1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate

2-Boc-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

2H-Pyrido[3,4-b]indole-2-carboxylic acid, 1,3,4,9-tetrahydro-, 1,1-dimethylethyl ester

tert-Butyl3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxyla

168824-94-0