ChemicalBook > CAS DataBase List > 2-Fluoroadenine

2-Fluoroadenine

Product Name
2-Fluoroadenine
CAS No.
700-49-2
Chemical Name
2-Fluoroadenine
Synonyms
2-Fluoro-9H-purin-6-amine;2-fluoro-7H-purin-6-aMine;2-fad;nsc27364;uoroadenine;TCMDC-124283;2-fluoro-adenin;2-FLUOROADENINE;BUTTPARK 25\01-01;2-Fluoroadenine>
CBNumber
CB9854134
Molecular Formula
C5H4FN5
Formula Weight
153.12
MOL File
700-49-2.mol
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2-Fluoroadenine Property

Melting point:
>350 °C(lit.)
Boiling point:
239.6±50.0 °C(Predicted)
Density 
2.05±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Sparingly, Sonicated, Heated), Methanol (Slightly, Heated)
form 
Solid
pka
6.84±0.20(Predicted)
color 
White to Light Yellow
CAS DataBase Reference
700-49-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36
WGK Germany 
3
RTECS 
AU6264700
Hazard Note 
Irritant
HazardClass 
IRRITANT, IRRITANT-HARMFUL
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
535087
Product name
2-Fluoroadenine
Purity
96%
Packaging
1g
Price
$146
Updated
2024/03/01
TCI Chemical
Product number
F0647
Product name
2-Fluoroadenine
Purity
>98.0%(HPLC)(T)
Packaging
200mg
Price
$18
Updated
2024/03/01
TCI Chemical
Product number
F0647
Product name
2-Fluoroadenine
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
30421
Product name
2-Fluoroadenine
Packaging
500mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
30421
Product name
2-Fluoroadenine
Packaging
1g
Price
$115
Updated
2024/03/01
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2-Fluoroadenine Chemical Properties,Usage,Production

Description

2-Fluoroadenine is a purine nucleoside analog which has been investigated for suicide gene therapy for human malignancy. It has been used in the synthesis of heat shock protein 90 (Hsp90) inhibitors that have anticancer activity in vitro. It is also cytotoxic to CEM human leukemia cells with an IC50 value of 0.15 μM.

Chemical Properties

white to light yellow crystal powder

Uses

A purine nucleoside phosphorylase gene therapy for human malignancy.

Uses

2-Fluoroadenine is a fluorinated heterocyclic 2-ring compound. It is the base moiety for many carbocyclic and acyclic nucleoside analogues, which may be used in antineoplastic studies. 2-Fluoroadenine has been used as an intermediate for antineoplastic drugs such as fludarabine. fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia.

Definition

ChEBI: 2-fluoroadenine is an organofluorine compound that is adenine in which the hydrogen at position 2 (the carbon between the two nitrogens of the pyrimidine ring) is replaced by a fluorine. It has a role as an antineoplastic agent. It is an organofluorine compound and a member of purines.

2-Fluoroadenine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoroadenine Suppliers

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View Lastest Price from 2-Fluoroadenine manufacturers

Henan Fengda Chemical Co., Ltd
Product
TCMDC-124283 700-49-2
Price
US $122.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-11
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Fluoroadenine 700-49-2
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg/month
Release date
2021-11-25
Henan Aochuang Chemical Co.,Ltd.
Product
2-Fluoroadenine 700-49-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-22

700-49-2, 2-FluoroadenineRelated Search:

Fludarabine phosphate FLAVIN ADENINE DINUCLEOTIDE Adenine Sulfate Adenine Sulfamic acid Acetaminophen EC 2.6.1.2 3-Aminobenzotrifluoride Fludarabine 5'-Adenylic acid, 2-amino- beta-D-Arabinofuranose (9CI) Fludarabine Phosphate EP Impurity A Fludarabine Phosphate iMpurity B Fludarabine Phosphate iMpurity F Fludarabine Phosphate EP Impurity C Inosine, 2-fluoro- 2-Fluoroadenosine 2-Fluoro-2',3',5'-triacetoxyadenosine

  • 2-fluoro-1h-purin-6-amin
  • 2-fluoro-1h-purin-6-amine
  • 2-fluoro-adenin
  • 6-amino-2-fluoro-purin
  • nsc27364
  • 2-Fluoro-9H-purin-6-amine
  • 6-Amino-2-fluoro-1H-purine
  • BUTTPARK 25\01-01
  • 2-FLUORO-6-AMINOPURINE
  • 2-FLUOROADENINE
  • 2-FLUORO-7(9)H-PURIN-6-YLAMINE
  • 6-AMINO-2-FLUOROPURINE
  • 2-fluoro-7H-purin-6-aMine
  • 2-Fluoro-9H-purin-6-amine, 2-Fluoroadenine
  • 6-Amino-2-fluoro-9H-purine
  • Fludarabine Phosphate EP Impurity D
  • 2-fad
  • Fludarabine Phosphate Impurity 4
  • uoroadenine
  • Fludarabine Phosphate impurity 4/Fludarabine Phosphate EP Impurity D/2-fluoroadenine
  • Fludarabine EP impurity D (2-Fluoroadenine )
  • Fludarabine EP impurity D
  • Fludarabine Phosphate Impurity 4（Fludarabine Phosphate EP Impurity D）
  • 2-Fluoroadenine&gt
  • 9H-Purin-6-amine, 2-fluoro-
  • 2-Fluoroadenine USP/EP/BP
  • 2-Fluoroadenine(700-49-2)
  • Fludarabine Impurity 5
  • TCMDC-124283
  • 700-49-2
  • C5H4FN5
  • C5H4N5F
  • Purines
  • Heterocyclic Building Blocks
  • Building Blocks
  • Biochemistry
  • Nucleobases and their analogs
  • Nucleosides, Nucleotides & Related Reagents
  • Purine
  • Chemical Amines
  • Purines
  • Bases & Related Reagents
  • Heterocycles
  • Nucleotides
  • Fused Ring Systems
  • Miscellaneous
  • Amines
  • bc0001