Oxyfedrine

Indications Mode of action Pharmacokinetics Side effects

Product Name: Oxyfedrine
CAS No.: 15687-41-9
Chemical Name: Oxyfedrine
Synonyms: oxyfedrine;Oxyfedrine USP/EP/BP;Oxyfedrine hydrochloride;3-[[(1R,2S)-2-Hydroxy-1-methyl-2-phenylethyl]amino]-1-(3-methoxyphenyl)-1-propanone;1-Propanone, 3-[[(1S,2R)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-(3-methoxyphenyl)-;3-{[(1S,2R)-2-Hydroxy-1-methyl-2-phenylethyl]amino}-1-[3-(methyloxy)phenyl]propan-1-one;(r-(r*,s*))-3-((2-hydroxy-1-methyl-2-phenylethyl)amino)-1-( 3-methoxyphenyl)-1-propanone
CBNumber: CB9854947
Molecular Formula: C19H23NO3
Formula Weight: 313.39
MOL File: 15687-41-9.mol

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Oxyfedrine Property

Melting point:: 107-109°C
Boiling point:: 475.2±28.0 °C(Predicted)
Density: 1.122±0.06 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly), Toluene (Slightly)
pka: 13.90±0.20(Predicted)
form: Solid
color: White to Off-White
Stability:: Hygroscopic, Moisture Sensitive

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: O870700
Product name: Oxyfedrine
Packaging: 5mg
Price: $215
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008730
Product name: OXYFEDRINE
Purity: 95.00%
Packaging: 10MG
Price: $367.5
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 60924
Product name: Oxyfedrine
Packaging: 100mg
Price: $2400
Updated: 2021/12/16

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Oxyfedrine Chemical Properties,Usage,Production

Indications

Oxyfedrine is a vasodilator and has been used in angina pectoris and myocardial infarction.

Mode of action

Vasodilator, beta-sympathomimetic due to its metabolite norephedrine.

Pharmacokinetics

Oxyfedrine is almost completely (75 to 100% of a dose) metabolized to norephedrine (see there), but the organ of biotransformation is not exactly known. It has not yet been decided whether oxyfedrine is metabolized by liver enzymes, as in rats, or is spontaneously degraded eventually in the duodenal fluid before absorption when administered orally. Both organs seem to be involved because the degree of metabolism is the same after parenteral or oral administration; however, entero-hepatic circulation is known.

Side effects

Reversible loss of taste sensation.

Originator

Ildamen,Homburg,W. Germany ,1966

Uses

Oxyfedrine acts as a vasodilator affecting the coronary base flow.

Definition

ChEBI: Oxyfedrine is an aromatic ketone.

Manufacturing Process

45 grams of m-methoxy acetophenone, 8 grams of paraformaldehyde and 30.2 grams of 1 norephedrine were mixed with about 135 cc of isopropanol HCl solution to provide a pH of 4 and the mixture refluxed for 4 hours. The reaction mixture was cooled and the crystals filtered off on a suction filter. 3[1-phenyl-1-hydroxypropyl-(2)-amino]-1-(m-methoxyphenyl)-propanone-(1) HCl was obtained which after recrystallization from methanol had a MP of 190° to 193°C.

Therapeutic Function

Coronary vasodilator

Oxyfedrine Preparation Products And Raw materials

Raw materials

DL-Norephedrine hydrochloride Paraformaldehyde Acetophenone 1,4-Dioxane

Preparation Products

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Oxyfedrine Suppliers

Canada 1 China 14 Europe 2 India 2 South Korea 1 United Kingdom 2 United States 12 Global 34

TargetMol Chemicals Inc.

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United States Biological

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Alfa Chemistry

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American Custom Chemicals Corporation

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Aces Pharma, Inc.

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AmplaChem, Inc.

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Wonda Science

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Waterstone Technology, LLC

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Altan Corporation

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2A PharmaChem USA

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3B Scientific Corporation

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AK Scientific, Inc.

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View Lastest Price from Oxyfedrine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Oxyfedrine 15687-41-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-11

15687-41-9, OxyfedrineRelated Search:

Kresoxim-methyl METSULFURON METHYL Bensulfuron methyl CHLOROPHOSPHONAZO III Methyl salicylate Methylparaben Thiophanate-methyl Methyl Methyl bromide Parathion-methyl OXYFEDRINE HCL,L-OXYFEDRINE HCL OXYFEDRINE Oxyfedrine

Oxyfedrine hydrochloride

(r-(r*,s*))-3-((2-hydroxy-1-methyl-2-phenylethyl)amino)-1-( 3-methoxyphenyl)-1-propanone

oxyfedrine

3-[[(1R,2S)-2-Hydroxy-1-methyl-2-phenylethyl]amino]-1-(3-methoxyphenyl)-1-propanone

3-{[(1S,2R)-2-Hydroxy-1-methyl-2-phenylethyl]amino}-1-[3-(methyloxy)phenyl]propan-1-one

1-Propanone, 3-[[(1S,2R)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-(3-methoxyphenyl)-

Oxyfedrine USP/EP/BP

15687-41-9

C19H23NO3