N-2-(4-bromobenzhydryloxy)ethyldimethylamine
- Product Name
- N-2-(4-bromobenzhydryloxy)ethyldimethylamine
- CAS No.
- 118-23-0
- Chemical Name
- N-2-(4-bromobenzhydryloxy)ethyldimethylamine
- Synonyms
- bromazine;Bromanautine;Histabromamine;Bromo-Benadryl;bromodiphenhydramine;Dimenhydrinate EP Impurity H;Diphenhydramine EP Impurity C;N-2-(4-bromobenzhydryloxy)ethyldimethylamine;2-benzhydryloxy-N-(bromomethyl)-N-methylethanamine;N-2-(4-bromobenzhydryloxy)ethyldimethylamine USP/EP/BP
- CBNumber
- CB9874781
- Molecular Formula
- C17H20BrNO
- Formula Weight
- 334.25
- MOL File
- 118-23-0.mol
N-2-(4-bromobenzhydryloxy)ethyldimethylamine Property
- Boiling point:
- 151-154 °C(Press: 0.3 Torr)
- Density
- 1.259±0.06 g/cm3(Predicted)
- pka
- pKa 8.64(H2O t = 25 c = 0.002 to 0.01) (Uncertain)
N-Bromosuccinimide Price
- Product number
- API0046163
- Product name
- DIPHENHYDRAMINE EP IMPURITY C
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $459.9
- Updated
- 2021/12/16
- Product number
- HCH0106088
- Product name
- BROMODIPHENHYDRAMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.58
- Updated
- 2021/12/16
N-2-(4-bromobenzhydryloxy)ethyldimethylamine Chemical Properties,Usage,Production
Originator
Bromazine,Shanghai Lansheng Corporation
Uses
Antihistaminic.
Definition
ChEBI: A tertiary amino compound that is the 4-bromobenzhydryl ether of 2-(dimethylamino)ethanol. An antihistamine with antimicrobial properties, it is used in the control of cutaneous allergies.
Manufacturing Process
28.1 parts of p-bromobenzhydrylbromide are heated to boiling, under reflux
and with stirring, with 50 parts of ethylene chlorohydrin and 5.3 parts of
calcined sodium carbonate. The reaction product is extracted with ether and
the etheral solution washed with water and dilute hydrochloric acid. The
residue from the solution in ether [p-bromobenzhydryl(β-chloroethyl)ether].
28.1 parts of this ether are heated with 12 parts of dimethylethylamine in a
sealed tube for 4 hours at 110°C. The product of the reaction is extracted
several time with dilute hydrochloric acid. The acid solution made alkaline, in
the cold, with concentrated caustic soda solution, and the base which
separates taken up in ether. The ether extract is washed with concentrated
potassium carbonate solution, evaporated down, and the residue distilled in
vacuo. Boiling point of p-bromo-α-phenylbenzyloxy)-N,N-dimethylethylamine
151-154°C under 0.3 mm.
p-Bromo-α-phenylbenzyloxy)-N,N-dimethylethylamine may be used as a
hydrochloride.
brand name
Ambodryl.
Therapeutic Function
Antihistaminic
N-2-(4-bromobenzhydryloxy)ethyldimethylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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