Anti-motion sickness Traits Effect Medicine interactions Precautions Adverse reactions Uses
ChemicalBook > CAS DataBase List > Dimenhydrinate

Dimenhydrinate

Anti-motion sickness Traits Effect Medicine interactions Precautions Adverse reactions Uses
Product Name
Dimenhydrinate
CAS No.
523-87-5
Chemical Name
Dimenhydrinate
Synonyms
emes;epha;DiMate;amosyt;dramyl;dromyl;emedyl;faston;gravol;vomexa
CBNumber
CB4308768
Molecular Formula
C17H21NO.C7H7ClN4O2
Formula Weight
469.97
MOL File
523-87-5.mol
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Dimenhydrinate Property

Melting point:
102-107°C
Density 
1.2586 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Slightly soluble in water, freely soluble in ethanol (96 per cent).
form 
Solid
color 
White to Off-White
Water Solubility 
Slightly soluble (0.1-1 g/100 mL at 22 ºC)
Stability:
Hygroscopic
InChIKey
NFLLKCVHYJRNRH-UHFFFAOYSA-N
CAS DataBase Reference
523-87-5(CAS DataBase Reference)
EPA Substance Registry System
Dimenhydrinate (523-87-5)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-61-36/37/38
Safety Statements 
22-26-36/37/39-53
WGK Germany 
3
RTECS 
XH5082000
TSCA 
Yes
HS Code 
2939590000
Hazardous Substances Data
523-87-5(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D2396
Product name
Dimenhydrinate
Packaging
10g
Price
$69.1
Updated
2024/03/01
Sigma-Aldrich
Product number
1206006
Product name
Dimenhydrinate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001103
Product name
Dimenhydrinate for peak identification
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001103
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1658
Product name
Dimenhydrinate
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$137
Updated
2024/03/01
Sigma-Aldrich
Product number
D2000000
Product name
Dimenhydrinate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
d2000000
Price
$150
Updated
2024/03/01
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Dimenhydrinate Chemical Properties,Usage,Production

Anti-motion sickness

Dimenhydrinate is a complex salt of diphenhydramine and 8-chloro-theophylline. Antihistamine effect is weaker than diphenhydramine , and its anti-motion sickness and antiemetic effects are stronger. Mainly it is used to prevent and control nausea, vomiting, dizziness and Meniere's syndrome caused by motion sickness, .It is effective to treat a variety of dizziness, vomiting caused by radiation therapy, pregnancy, surgery, inner ear infections, and the use of drugs (such as streptomycin) .

Traits

Dimenhydrinate is transparent white crystalline powder, odorless, slightly soluble in water, soluble in ethanol.

Effect

As a complex salt of diphenhydramine and 8-chloro-theophylline,its role is the same as diphenhydramine hydrochloride, but its anti-histamine effect is weaker than the latter. It can inhibit medulla vomiting chemosensory area and it has a general central pivot inhibition effect and anticholinergic effects, which makes it have sedative and antiemetic effects.
It is quickly and completely absorbed after oral administration, it is effective after 15 to 60 minutes , the role is sustainable after 3-6 hours, the elimination phase half-life (t1/2β) is 4~6 hours, plasma protein binding rate is high. Mainly it is metabolized in the liver, it is excreted in urine in the form of metabolites . Patients with hepatic insufficiency using this service,because it can accumulate in the body , the dose should be reduced.
The above information is edited by the chemicalbook of Tian Ye.

Medicine interactions

1.It can not be taken with other CNS depressants and it cannot be taken after drinking.
2. It can be used to make ethanol, central nervous system depressants, tricyclic antidepressants more effective. It can momentarily affect barbiturates and sulfacetamide sodium absorption; if it is used with sodium aminosalicylate , plasma concentration of the latter is decreased.
3. Administration with food or milk can reduce the irritation of the stomach of the drug .

Precautions

1. The composition of the production and other ethanolamine allergies, newborns and premature infants are disabled.
2. It pregnant women in early pregnancy within four months use the drug, the incidence of congenital cardiovascular abnormalities and inguinal hernia of the fetus may be increased, the relationship with drug use has not been confirmed. Early pregnancy should not take this product.
3. The anti-emetic effect of the product can adds difficulty in diagnosing appendicitis and drug-induced reactions.
4. Lethargy , inability to concentrate etc.,can occur after treatment, ,patients should not drive cars, boats, etc., and it is not suitable to engage in the highly difficult and dangerous machine operation.

Adverse reactions

Low toxicity, high doses can cause drowsiness, and even cause a rash. Long-term use may cause blood diseases.

Uses

It is suitable for motion-sickness, pregnancy, radiation therapy , surgery etc. induced nausea , vomiting and dizziness.

Description

Dimenhydrinate (16.1.2) is a complex compound of N, N-dimethyl (2- diphenylmethoxy)ethylamine—diphenhydramine with 8-chlorotheophylline. While blocking the H1 receptor, dimenhydrinate simultaneously acts on the vomiting center.

Chemical Properties

White Solid
Dimenhydrinate is freely soluble in ethanol and chloroform, slightly soluble in water, and almost in-soluble in ether.

Originator

Dramamine,Searle,US,1949

Uses

Dimenhydrinate is used for preventing and stopping sea or airsickness, and for nausea and vomiting. Synonyms of this drug are dramamine, dadalon, emedyl, travelin, and others.

Uses

An antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).

Uses

Used for treating vertigo, motion sickness, and nausea associated with pregnancy

Definition

ChEBI: The diphenhydramine salt of 8-chlorotheophylline. Its effects are similar to those of diphenhydramine, but it is less potent. It was thought that by combining the antiemetic effects of diphenhydramine with the mild stimulant effects of 8-chlorotheophyline, the extreme drowsiness induced by the former would be mitigated. However, the sedation caused by diphenhydramine is considerably stronger than the stimulation caused by 8-chlorotheophylline. Dimenhydrinate is used mainly as an antiemetic in the prevention nd treatment of motion sickness.

Manufacturing Process

58.8 grams of 8-chlorotheophylline and 70 grams of β-dimethylaminoethyl benzohydryl ether are dissolved in 150 cc of hot methanol. Then 5 grams of activated charcoal are added and the mixture is boiled for an hour. It is filtered hot and the filtrate cooled. The crystalline precipitate of βdimethylaminoethyl benzohydryl ether 8-chlorotheophyllinate is collected on a filter, washed with ether and dried. It melts at 96-99°C. It is dissolved in boiling ethyl acetate, filtered hot to remove any insoluble material, and then chilled. The salt so obtained melts at 102.5°-104°C after filtration, washing with ether and drying.

brand name

Dommanate (Forest).

Therapeutic Function

Antinauseant

General Description

The 8-chlorotheophyllinate (theoclate) salt of diphenhydramine, 8-chlorotheophylline 2-(diphenylmethoxy)-N,N-dimethylethylamine (Dramamine), is a white crystalline, odorless powder that is highly soluble in water and freely soluble in alcohol and chloroform. Dimenhydrinate is recommended for nausea of motion sickness and for hyperemesis gravidarum (nausea of pregnancy).

General Description

Crystalline white powder.

Air & Water Reactions

Slightly soluble in water. Slightly acidic.

Health Hazard

SYMPTOMS: Symptoms associated with Dimenhydrinate include: drowsiness, lethargy, fatigue hypnosis and coma. Initial sedation may be followed by central nervous system hyperexcitability. Also, the victim may experience dry mouth, anorexia, nausea, vomiting, abdominal distress, constipation, and/or diarrhea.

Fire Hazard

Flash point data for Dimenhydrinate are not available but Dimenhydrinate is probably non-flammable.

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. A drug much used for motion sickness. Human systemic effects by ingestion: arrhythmias, convulsions, distorted perceptions, hallucinations, intracranial pressure increase. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx, and Cl-. See also AMINES.

Veterinary Drugs and Treatments

In veterinary medicine, dimenhydrinate is used primarily for its antiemetic effects for vomiting and in the prophylactic treatment of motion sickness in dogs and cats. Dimenhydrinate may be useful as an adjunctive treatment for feline pancreatitis. As dimenhydrinate is often thought of as “half-strength diphenhydramine” it can be employed whenever a histmine-1 blocker is desired.

Dimenhydrinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Dimenhydrinate Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8836
Advantage
52
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Fax
+86 755 28094224
Country
China
ProdList
4496
Advantage
50
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
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View Lastest Price from Dimenhydrinate manufacturers

Sinoway Industrial co., ltd.
Product
Dimenhydrinate 523-87-5
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
USP
Supply Ability
20 tons
Release date
2021-09-09
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Dimenhydrinate 523-87-5
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
Diphenhydramine:53.0%-55.5% 8-Chlorotheophylline:44.0%-47.0%
Supply Ability
1000KGS
Release date
2021-08-12
Hangzhou Hyper Chemicals Limited
Product
Dimenhydrinate 523-87-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
USP, BP
Supply Ability
5,000KG
Release date
2024-06-13

523-87-5, DimenhydrinateRelated Search:


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