ChemicalBook > CAS DataBase List > N-2-(4-bromobenzhydryloxy)ethyldimethylamine

N-2-(4-bromobenzhydryloxy)ethyldimethylamine

Product Name
N-2-(4-bromobenzhydryloxy)ethyldimethylamine
CAS No.
118-23-0
Chemical Name
N-2-(4-bromobenzhydryloxy)ethyldimethylamine
Synonyms
bromazine;Bromanautine;Histabromamine;Bromo-Benadryl;bromodiphenhydramine;Dimenhydrinate EP Impurity H;Diphenhydramine EP Impurity C;N-2-(4-bromobenzhydryloxy)ethyldimethylamine;2-benzhydryloxy-N-(bromomethyl)-N-methylethanamine;N-2-(4-bromobenzhydryloxy)ethyldimethylamine USP/EP/BP
CBNumber
CB9874781
Molecular Formula
C17H20BrNO
Formula Weight
334.25
MOL File
118-23-0.mol
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N-2-(4-bromobenzhydryloxy)ethyldimethylamine Property

Boiling point:
151-154 °C(Press: 0.3 Torr)
Density 
1.259±0.06 g/cm3(Predicted)
pka
pKa 8.64(H2O t = 25 c = 0.002 to 0.01) (Uncertain)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0046163
Product name
DIPHENHYDRAMINE EP IMPURITY C
Purity
95.00%
Packaging
5MG
Price
$459.9
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0106088
Product name
BROMODIPHENHYDRAMINE
Purity
95.00%
Packaging
5MG
Price
$505.58
Updated
2021/12/16
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N-2-(4-bromobenzhydryloxy)ethyldimethylamine Chemical Properties,Usage,Production

Originator

Bromazine,Shanghai Lansheng Corporation

Uses

Antihistaminic.

Definition

ChEBI: A tertiary amino compound that is the 4-bromobenzhydryl ether of 2-(dimethylamino)ethanol. An antihistamine with antimicrobial properties, it is used in the control of cutaneous allergies.

Manufacturing Process

28.1 parts of p-bromobenzhydrylbromide are heated to boiling, under reflux and with stirring, with 50 parts of ethylene chlorohydrin and 5.3 parts of calcined sodium carbonate. The reaction product is extracted with ether and the etheral solution washed with water and dilute hydrochloric acid. The residue from the solution in ether [p-bromobenzhydryl(β-chloroethyl)ether].
28.1 parts of this ether are heated with 12 parts of dimethylethylamine in a sealed tube for 4 hours at 110°C. The product of the reaction is extracted several time with dilute hydrochloric acid. The acid solution made alkaline, in the cold, with concentrated caustic soda solution, and the base which separates taken up in ether. The ether extract is washed with concentrated potassium carbonate solution, evaporated down, and the residue distilled in vacuo. Boiling point of p-bromo-α-phenylbenzyloxy)-N,N-dimethylethylamine 151-154°C under 0.3 mm.
p-Bromo-α-phenylbenzyloxy)-N,N-dimethylethylamine may be used as a hydrochloride.

brand name

Ambodryl.

Therapeutic Function

Antihistaminic

N-2-(4-bromobenzhydryloxy)ethyldimethylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-2-(4-bromobenzhydryloxy)ethyldimethylamine Suppliers

China 21 India 5 United States 5 Global 31
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118-23-0, N-2-(4-bromobenzhydryloxy)ethyldimethylamineRelated Search:

Dimenhydrinate Bromazine Hydrochloride 1-(4-Bromophenyl)ethanol embramine 4-BROMOBENZHYDROL embramine hydrochloride N-2-(4-bromobenzhydryloxy)ethyldimethylamine

  • bromazine
  • bromodiphenhydramine
  • N-2-(4-bromobenzhydryloxy)ethyldimethylamine
  • Ethanamine, 2-(4-bromophenyl)phenylmethoxy-N,N-dimethyl-
  • Bromanautine
  • Bromo-Benadryl
  • Histabromamine
  • Diphenhydramine EP Impurity C
  • 2-benzhydryloxy-N-(bromomethyl)-N-methylethanamine
  • Dimenhydrinate EP Impurity H
  • 2-((4-Bromophenyl)(phenyl)methoxy)-N,N-dimethylethanamine
  • N-2-(4-bromobenzhydryloxy)ethyldimethylamine USP/EP/BP
  • Dimenhydrinate Impurity 8 (Dimenhydrinate EP Impurity H)
  • Dimenhydrinate EP Impurity HQ: What is Dimenhydrinate EP Impurity H Q: What is the CAS Number of Dimenhydrinate EP Impurity H
  • 2-[(RS)-(4-Bromophenyl)phenylmethoxy]-N,N-dimethylethanamine
  • 2-[(RS)-(4-bromophenyl)-(phenyl)methoxy]-N,N-dimethylethanamine (4-bromodiphenhydramine),
  • Diphenhydramine EP Impurity C（Dimenhydrinate EP Impurity H）
  • 118-23-0