Epitiostanol Property

Melting point:

127-128°

alpha 

D27.5 +24.4° (c = 1.054 in chloroform)

Boiling point:

417.1°C (rough estimate)

Density 

1.0122 (rough estimate)

refractive index 

1.5700 (estimate)

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

pka

15.10±0.60(Predicted)

color 

White to Off-White

Water Solubility 

1.2mg/L(37 ºC)

Safety

Toxicity

LD50 in mice, rats (mg/kg): 1, 5 i.p. (Minesita, p 805)

Hazard and Precautionary Statements (GHS)

Epitiostanol Chemical Properties,Usage,Production

Originator

Thiodrol,Shionogi,Japan,1977

Uses

An anabolic steroid that exhibits androgenic, myogenic, anabolic, anticatabolic, progestational, deciduomatogenic, and antiestrogenic activities. An anti-estrogen with anti-mammry cancer agent.

Definition

ChEBI: Epitiostanol is an organic molecular entity.

Manufacturing Process

A solution of 2β-thiocyanato-3α-methanesulfonyloxy-5α-androstan-17β-ol 17- acetate (0.82 part by weight) and potassium hydroxide (0.9 part by weight) in diglyme (20 parts by volume) is refluxed on a water bath for 24 hours while stirring. To the reaction mixture, there is added water, and the separated substance is collected by filtration and crystallized from hexane to give 2β,3β- epithio-5α-androstan-17β-ol (0.60 part by weight) as crystals melting at 132.5°C to 134°C.

Therapeutic Function

Antineoplastic