Avermectin A1a, 5-O-demethyl-22,23-dihydro-
- Product Name
- Avermectin A1a, 5-O-demethyl-22,23-dihydro-
- CAS No.
- 71827-03-7
- Chemical Name
- Avermectin A1a, 5-O-demethyl-22,23-dihydro-
- Synonyms
- Ivermectin B1a;IvermectinH2B1a;Ivermectin B1a (>85%);Ivermectin Impurity 3;Dihydroavermectin B1a;22,23-dihydroavermectin B1a in Methanol;5-O-Demethyl-22,23-dihydroavermectin A1a;22,23-Dihydro-5-O-demethylavermectin A1a;Avermectin A1a, 5-O-demethyl-22,23-dihydro-;Ivermectin 2-epimer (Dihydro Avermectin B1a)
- CBNumber
- CB9928288
- Molecular Formula
- C48H74O14
- Formula Weight
- 875.09
- MOL File
- 71827-03-7.mol
Avermectin A1a, 5-O-demethyl-22,23-dihydro- Property
- Melting point:
- 155-157°
- Boiling point:
- 717.97°C (rough estimate)
- Density
- 1.0683 (rough estimate)
- refractive index
- 1.6130 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- solid
- pka
- 12.42±0.70(Predicted)
- color
- white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 18768
- Product name
- Ivermectin B1a
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $127
- Updated
- 2024/03/01
- Product number
- 18768
- Product name
- Ivermectin B1a
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $567
- Updated
- 2024/03/01
- Product number
- C3905
- Product name
- IvermectinB1a
- Packaging
- 25mg
- Price
- $618
- Updated
- 2021/12/16
- Product number
- C3905
- Product name
- IvermectinB1a
- Packaging
- 5mg
- Price
- $138
- Updated
- 2021/12/16
- Product number
- CS-0108408
- Product name
- IvermectinB1a
- Purity
- ≥99.0%
- Packaging
- 5mg
- Price
- $450
- Updated
- 2021/12/16
Avermectin A1a, 5-O-demethyl-22,23-dihydro- Chemical Properties,Usage,Production
Description
Ivermectin B1a is the main component (>80%) of the anthelmintic ivermectin, which also contains ivermectin B1b (<20%; ). It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening and very long-lasting hyperpolarization/depolarization of the neuron/muscle cell, thereby blocking further function (EC50 = 104 nM). Formulations containing ivermectin inhibit replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero/hSLAM cells.
Uses
Ivermectin B1a-D2 is a deuterium labelled analogue of Ivermectin B1a (I940815), which is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.
Definition
ChEBI: A macrocyclic lactone that is avermectin B1a in which the double bond present in the spirocyclic ring system has been reduced to a single bond. It is the major component of ivermectin.
References
[1] j. wolsetnholme and a. t. rogers. glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. parasitology131 suppl, s85-s95 (2005).
[2] s. gaisser, l. kellenberger, a. l. kaja, et al. direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of streptomyces avermitilis atcc31272. organic & biomolecular chemistry 1(16), 2840-2847 (2003).
[3] j. p. arena, k. k. liu, p. s. paress, et al. the mechanism of action of avermectins in caenorhabditis elegans: correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity. journal of parasitology 81, 286-294 (1995).
Avermectin A1a, 5-O-demethyl-22,23-dihydro- Preparation Products And Raw materials
Raw materials
Preparation Products
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