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Avermectin A1a, 5-O-demethyl-22,23-dihydro-

Product Name
Avermectin A1a, 5-O-demethyl-22,23-dihydro-
CAS No.
71827-03-7
Chemical Name
Avermectin A1a, 5-O-demethyl-22,23-dihydro-
Synonyms
Ivermectin B1a;IvermectinH2B1a;Ivermectin B1a (>85%);Ivermectin Impurity 3;Dihydroavermectin B1a;22,23-dihydroavermectin B1a in Methanol;5-O-Demethyl-22,23-dihydroavermectin A1a;22,23-Dihydro-5-O-demethylavermectin A1a;Avermectin A1a, 5-O-demethyl-22,23-dihydro-;Ivermectin 2-epimer (Dihydro Avermectin B1a)
CBNumber
CB9928288
Molecular Formula
C48H74O14
Formula Weight
875.09
MOL File
71827-03-7.mol
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Avermectin A1a, 5-O-demethyl-22,23-dihydro- Property

Melting point:
155-157°
Boiling point:
717.97°C (rough estimate)
Density 
1.0683 (rough estimate)
refractive index 
1.6130 (estimate)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
solid
pka
12.42±0.70(Predicted)
color 
white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18768
Product name
Ivermectin B1a
Purity
≥95%
Packaging
5mg
Price
$127
Updated
2024/03/01
Cayman Chemical
Product number
18768
Product name
Ivermectin B1a
Purity
≥95%
Packaging
25mg
Price
$567
Updated
2024/03/01
ApexBio Technology
Product number
C3905
Product name
IvermectinB1a
Packaging
25mg
Price
$618
Updated
2021/12/16
ApexBio Technology
Product number
C3905
Product name
IvermectinB1a
Packaging
5mg
Price
$138
Updated
2021/12/16
ChemScene
Product number
CS-0108408
Product name
IvermectinB1a
Purity
≥99.0%
Packaging
5mg
Price
$450
Updated
2021/12/16
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Avermectin A1a, 5-O-demethyl-22,23-dihydro- Chemical Properties,Usage,Production

Description

Ivermectin B1a is the main component (>80%) of the anthelmintic ivermectin, which also contains ivermectin B1b (<20%; ). It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening and very long-lasting hyperpolarization/depolarization of the neuron/muscle cell, thereby blocking further function (EC50 = 104 nM). Formulations containing ivermectin inhibit replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero/hSLAM cells.

Uses

Ivermectin B1a-D2 is a deuterium labelled analogue of Ivermectin B1a (I940815), which is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.

Definition

ChEBI: A macrocyclic lactone that is avermectin B1a in which the double bond present in the spirocyclic ring system has been reduced to a single bond. It is the major component of ivermectin.

References

[1] j. wolsetnholme and a. t. rogers. glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. parasitology131 suppl, s85-s95 (2005).
[2] s. gaisser, l. kellenberger, a. l. kaja, et al. direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of streptomyces avermitilis atcc31272. organic & biomolecular chemistry 1(16), 2840-2847 (2003).
[3] j. p. arena, k. k. liu, p. s. paress, et al. the mechanism of action of avermectins in caenorhabditis elegans: correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity. journal of parasitology 81, 286-294 (1995).

Avermectin A1a, 5-O-demethyl-22,23-dihydro- Preparation Products And Raw materials

Raw materials

Preparation Products

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Avermectin A1a, 5-O-demethyl-22,23-dihydro- Suppliers

China 47 India 5 United States 7 Global 59
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71827-03-7, Avermectin A1a, 5-O-demethyl-22,23-dihydro-Related Search:

3,4-Dihydro IverMectin :Ivermectin B1a monosaccharide Avermectin B1a Ivermectin Ivermectin aglycone Avermectin B1b 28-Oxo IverMectin B1a (IMpurity) 2-Methyltetrahydropyran Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)- rac-2,3-Dehydro-3,4-dihydro IverMectin IverMectin B1 Aglycon Ivermectin

  • 22,23-Dihydro-5-O-demethylavermectin A1a
  • 5-O-Demethyl-22,23-dihydroavermectin A1a
  • Dihydroavermectin B1a
  • Ivermectin B1a
  • IvermectinH2B1a
  • (2Ae,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17ar,20R,20ar,20bs)-20,20B-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-3',4',5',6,6',10,11,14,15,17,17A,20,20A,20B-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-o-(2,6-dideoxy-3-o-methyl-alpha-L-arabino-hexopyranosyl)-3-o-methyl-alpha-L-arabino-hexopyranoside
  • Avermectin A1a, 5-O-demethyl-22,23-dihydro-
  • Ivermectin Impurity 3
  • Ivermectin B1a (>85%)
  • Ivermectin B1a-D2Q: What is Ivermectin B1a-D2 Q: What is the CAS Number of Ivermectin B1a-D2
  • Avermectin,Ivermectin,B1a,COVID-19,Parasite,Inhibitor,SARS coronavirus,Ivermectin B1a,anti-parasite,inhibit,SARS-CoV
  • Ivermectin 2-epimer (Dihydro Avermectin B1a)
  • 22,23-dihydroavermectin B1a in Methanol
  • 71827-03-7
  • Organics