ChemicalBook > CAS DataBase List > methyl tosylcarbamate
methyl tosylcarbamate
- Product Name
- methyl tosylcarbamate
- CAS No.
- 14437-03-7
- Chemical Name
- methyl tosylcarbamate
- Synonyms
- Einecs 238-411-4;methyl tosylcarbamate;Gliclazide Impurity 19;Methyl N-(p-Tosyl)carbaMate;N-Tosylcarbamic acid methyl ester;N-(p-Tosyl)carbaMic Acid Methyl Ester;Methyl N-(p-toluenesulfonyl)carbaMate;N-(Methoxycarbonyl)-p-toluenesulfonamide;METHYL (4-METHYLPHENYL)SULFONYLCARBAMATE;methyl N-(4-methylphenyl)sulfonylcarbamate
- CBNumber
- CB9937628
- Molecular Formula
- C9H11NO4S
- Formula Weight
- 229.25
- MOL File
- 14437-03-7.mol
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methyl tosylcarbamate Property
- Melting point:
- 115 °C
- Density
- 1.300±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly) , Methanol (Slightly)
- pka
- 4.76±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- R746495
- Product name
- METHYL (4-METHYLPHENYL)SULFONYLCARBAMATE
- Purity
- AldrichCPR
- Packaging
- 25MG
- Price
- $30.7
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M2988
- Product name
- Methyl Tosylcarbamate
- Packaging
- 1G
- Price
- $96
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M2988
- Product name
- Methyl Tosylcarbamate
- Packaging
- 10G
- Price
- $576
- Updated
- 2025/07/31
TRC
- Product number
- T630200
- Product name
- N-(p-Tosyl)carbamicAcidMethylEster
- Packaging
- 10g
- Price
- $1210
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CHM1039531
- Product name
- CARBMIC ACID, N-[(4-METHYLPHENYL)SULFONYL]-, METHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.59
- Updated
- 2021/12/16
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methyl tosylcarbamate Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
N-(p-Tosyl)carbamic Acid Methyl Ester is a degradation product of Gliclazide.
Synthesis
70-55-3
79-22-1
14437-03-7
General method: 4-substituted benzenesulfonamides were dissolved in anhydrous dichloromethane and the solution was cooled to 0°C in an ice bath. Subsequently, trimethylamine was slowly added dropwise to the reaction system. The reaction temperature was maintained at 0 °C and after continuous stirring for 10 min, methyl chloroformate was added dropwise. Stirring of the reaction mixture was continued at 0°C for 30 minutes. The ice bath was removed and the reaction mixture was allowed to gradually warm up to room temperature over 2 hours. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and the organic phase was washed sequentially with 1 M aqueous hydrochloric acid, water and saturated brine. The organic layer was dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford the target product, methyl 4-substituted (phenylsulfonyl)carbamate.
References
[1] Journal of the Chinese Chemical Society, 2007, vol. 54, # 3, p. 771 - 777
[2] Organic Process Research and Development, 2016, vol. 20, # 2, p. 440 - 445
[3] Tetrahedron Letters, 2016, vol. 57, # 13, p. 1476 - 1478
[4] Journal of Medicinal Chemistry, 2004, vol. 47, # 3, p. 627 - 643
[5] Journal of Medicinal Chemistry, 2017, vol. 60, # 3, p. 1126 - 1141
methyl tosylcarbamate Preparation Products And Raw materials
Raw materials
Preparation Products
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14437-03-7, methyl tosylcarbamateRelated Search:
Gliclazide EP Impurity E
Gliclazide
Gliclazide Impurity (Methyl N-Methyl-p-Tolysulphoncarbomate)
Gliclazide EP Impurity G
N-[[(HEXAHYDROCYCLOPENTA [C]PYRROL-2(1H)-YL)AMINO]CARBONYL]-2-METHYL BENZENESULFONAMIDE
octahydro-2-nitrosocyclopenta[c]pyrrole
Gliclazide iMpurity D
Carboxy Gliclazide
Ethyl N-(4-methylphenyl)sulfonylcarbamate
[[4-[2-[[(3-Ethyl-2,5-dihydro-4-methyl-2-oxo-1H-pyrrol-1-yl)carbonyl]amino]ethyl]phenyl]sulfonyl]-carbamic acid ethyl ester
methyl tosylcarbamate
N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE
N-(4-BROMO-2-BUTYNYL)-N-(TERT-BUTYLOXYCARBONYL)(4-METHYLPHENYL)SULFONAMIDE
1-(6-METHYL[1,3]THIAZOLO[3,2-B][1,2,4]TRIAZOL-5-YL)ETHYL N-[(4-METHYLPHENYL)SULFONYL]CARBAMATE
ETHYL 4-[2-(5-CHLORO-2-METHOXYBENZAMIDO)ETHYL]BENZENE SULFONAMIDE CARBAMATE
25,27-DIMETHOXY-26-(N-TOSYL)CARBOMOYLOXYCALIX[4]ARENE
Tosular
[5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL]METHYL N-[(4-METHYLPHENYL)SULFONYL]CARBAMATE