Ethyl N-(4-methylphenyl)sulfonylcarbamate

Product Name: Ethyl N-(4-methylphenyl)sulfonylcarbamate
CAS No.: 5577-13-9
Chemical Name: Ethyl N-(4-methylphenyl)sulfonylcarbamate
Synonyms: Tosylurethane;ethyl tosylcarbaMate;Gliclazide IMpurity C;Gliclazide EP Impurity C;Tosylcarbamic acid ethyl ester;Ethyl [(4-Methylphenyl)sulphonyl]ca;ethyl n-(4-methylphenyl)sulfonylcarbamate;Ethyl [(4-methylphenyl)sulfonyl]-carbamate;Ethyl [(4-methylphenyl)sulphonyl]carbamate;Ethyl N-(4-methylbenzenesulfonyl)carbamate
CBNumber: CB7512137
Molecular Formula: C10H13NO4S
Formula Weight: 243.28
MOL File: 5577-13-9.mol

More

Less

Ethyl N-(4-methylphenyl)sulfonylcarbamate Property

Melting point:: 82-84oC
Boiling point:: 272℃ at 100.8-101kPa
Density: 1.38 at 20℃
vapor pressure: 1.8-7.9Pa at 20-25℃
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
color: White
LogP: 0.73-1.7 at 23℃ and pH2-7
Surface tension: 63.8mN/m at 1g/L and 20℃

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

TRC

Product number: T686900
Product name: Tosylurethane
Packaging: 10g
Price: $1155
Updated: 2021/12/16

AK Scientific

Product number: 8144AB
Product name: Ethyltosylcarbamate
Packaging: 10g
Price: $311
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0311940
Product name: ETHYL-4-TOLYLSULFONYLCARBAMATE
Purity: 95.00%
Packaging: 5MG
Price: $500.35
Updated: 2021/12/16

AK Scientific

Product number: 8144AB
Product name: Ethyltosylcarbamate
Packaging: 25g
Price: $695
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 49002
Product name: Tosylurethane
Packaging: 10g
Price: $2000
Updated: 2021/12/16

More

Less

Ethyl N-(4-methylphenyl)sulfonylcarbamate Chemical Properties,Usage,Production

Uses

Tosylurethane (Gliclazide EP Impurity C) is an intermediate in the synthesis of Gliclazide (G409877), a sulfonylurea hypoglycemic agent. Used as an antidiabetic.

Synthesis

64-17-5

31224-37-0

5577-13-9

GENERAL STEPS: Dissolve 4-methylphenylsulfonylcarbamate (Compound, CAS:31224-37-0) in selected alcohol (ethanol, 2 mL) in a microwaveable reaction vial. The reaction vial was sealed using an aluminum cap with a PTFE-faced septum. The reaction mixture was placed in a microwave reactor and radiantly heated at 100-120°C for 20-60 min. Upon completion of the reaction, the crude product was concentrated under reduced pressure and the residue was subsequently purified by silica gel column chromatography to finally obtain the target product, ethyl N-(4-methylphenyl)sulfonylcarbamate.

References

[1] Tetrahedron Letters, 2016, vol. 57, # 13, p. 1476 - 1478

Ethyl N-(4-methylphenyl)sulfonylcarbamate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Ethyl N-(4-methylphenyl)sulfonylcarbamate Suppliers

China 78 France 1 Germany 1 India 8 United Kingdom 1 United States 17 Global 106

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 5158
Advantage: 50

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

Cantotech Chemicals, Ltd.

Tel: 86-0755-86635001
Fax: 86-0755-22642228
Email: cantotech@126.com
Country: China
ProdList: 4566
Advantage: 55

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Beijing FYF Chemicals Co., Ltd

Tel: 010-57903446 15869909019
Fax: 010-57903446
Email: 168931144@qq.com
Country: China
ProdList: 2875
Advantage: 58

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

5577-13-9, Ethyl N-(4-methylphenyl)sulfonylcarbamateRelated Search:

Trinexapac-ethyl Ethyl imidazole-4-carboxylate Ethyl acetate Ethanol Urethane Ethylparaben Ethyl acrylate Ethyl propiolate Benzocaine Ethyl cyanoacetate Chlorpropham ISOXADIFEN-ETHYL N-Des(5-Methylpyrazinecarbonyl)-N-ethylcarboxyl Glipizide GLIMEPIRIDE RELATED COMPOUND C (20 MG) (GLIMEPIRIDE URETHANE) GliMepiride EP IMpurity F N-Des(cyclohexylaMinocarbonyl) Glipizide 5-DesMethyl-6-Methyl Glipizide ortho-GliMepiride IMpurity

ethyl n-(4-methylphenyl)sulfonylcarbamate

Ethyl [(4-methylphenyl)sulphonyl]carbamate

N-(p-Tolylsulfonyl)carbamic acid ethyl ester

Tosylcarbamic acid ethyl ester

N-(4-methylphenyl)sulfonylcarbamic acid ethyl ester

3-ethyl-4-methylbenzenesulfonic acid carbamoyl ester

ethyl tosylcarbaMate

Gliclazide IMpurity C

Tosylurethane

Gliclazide EP Impurity C

Ethyl [(4-methylphenyl)sulfonyl]-carbamate

Gliclazide Impurity 3(Gliclazide EP Impurity C)

Ethyl [(4-Methylphenyl)sulphonyl]ca

Carbamic acid, N-[(4-methylphenyl)sulfonyl]-, ethyl ester

Ethyl N-(4-methylbenzenesulfonyl)carbamate

Gliclazide EP Impurity C Gliclazide BP Impurity C

5577-13-9