methyl tosylcarbamate

Product Name: methyl tosylcarbamate
CAS No.: 14437-03-7
Chemical Name: methyl tosylcarbamate
Synonyms: Einecs 238-411-4;methyl tosylcarbamate;Gliclazide Impurity 19;Methyl N-(p-Tosyl)carbaMate;N-Tosylcarbamic acid methyl ester;N-(p-Tosyl)carbaMic Acid Methyl Ester;Methyl N-(p-toluenesulfonyl)carbaMate;N-(Methoxycarbonyl)-p-toluenesulfonamide;METHYL (4-METHYLPHENYL)SULFONYLCARBAMATE;methyl N-(4-methylphenyl)sulfonylcarbamate
CBNumber: CB9937628
Molecular Formula: C9H11NO4S
Formula Weight: 229.25
MOL File: 14437-03-7.mol

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methyl tosylcarbamate Property

Melting point:: 115 °C
Density: 1.300±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Ethyl Acetate (Slightly) , Methanol (Slightly)
pka: 4.76±0.10(Predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R746495
Product name: METHYL (4-METHYLPHENYL)SULFONYLCARBAMATE
Purity: AldrichCPR
Packaging: 25MG
Price: $30.7
Updated: 2025/07/31

TCI Chemical

Product number: M2988
Product name: Methyl Tosylcarbamate
Packaging: 1G
Price: $96
Updated: 2025/07/31

TCI Chemical

Product number: M2988
Product name: Methyl Tosylcarbamate
Packaging: 10G
Price: $576
Updated: 2025/07/31

TRC

Product number: T630200
Product name: N-(p-Tosyl)carbamicAcidMethylEster
Packaging: 10g
Price: $1210
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1039531
Product name: CARBMIC ACID, N-[(4-METHYLPHENYL)SULFONYL]-, METHYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $499.59
Updated: 2021/12/16

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methyl tosylcarbamate Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

N-(p-Tosyl)carbamic Acid Methyl Ester is a degradation product of Gliclazide.

Synthesis

70-55-3

79-22-1

14437-03-7

General method: 4-substituted benzenesulfonamides were dissolved in anhydrous dichloromethane and the solution was cooled to 0°C in an ice bath. Subsequently, trimethylamine was slowly added dropwise to the reaction system. The reaction temperature was maintained at 0 °C and after continuous stirring for 10 min, methyl chloroformate was added dropwise. Stirring of the reaction mixture was continued at 0°C for 30 minutes. The ice bath was removed and the reaction mixture was allowed to gradually warm up to room temperature over 2 hours. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and the organic phase was washed sequentially with 1 M aqueous hydrochloric acid, water and saturated brine. The organic layer was dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford the target product, methyl 4-substituted (phenylsulfonyl)carbamate.

References

[1] Journal of the Chinese Chemical Society, 2007, vol. 54, # 3, p. 771 - 777
[2] Organic Process Research and Development, 2016, vol. 20, # 2, p. 440 - 445
[3] Tetrahedron Letters, 2016, vol. 57, # 13, p. 1476 - 1478
[4] Journal of Medicinal Chemistry, 2004, vol. 47, # 3, p. 627 - 643
[5] Journal of Medicinal Chemistry, 2017, vol. 60, # 3, p. 1126 - 1141

methyl tosylcarbamate Preparation Products And Raw materials

Raw materials

Preparation Products

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methyl tosylcarbamate Suppliers

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14437-03-7, methyl tosylcarbamateRelated Search:

Gliclazide EP Impurity E Gliclazide Gliclazide Impurity (Methyl N-Methyl-p-Tolysulphoncarbomate) Gliclazide EP Impurity G N-[[(HEXAHYDROCYCLOPENTA [C]PYRROL-2(1H)-YL)AMINO]CARBONYL]-2-METHYL BENZENESULFONAMIDE octahydro-2-nitrosocyclopenta[c]pyrrole Gliclazide iMpurity D Carboxy Gliclazide Ethyl N-(4-methylphenyl)sulfonylcarbamate [[4-[2-[[(3-Ethyl-2,5-dihydro-4-methyl-2-oxo-1H-pyrrol-1-yl)carbonyl]amino]ethyl]phenyl]sulfonyl]-carbamic acid ethyl ester methyl tosylcarbamate N-(TERT-BUTOXYCARBONYL)-P-TOLUENESULFONAMIDE N-(4-BROMO-2-BUTYNYL)-N-(TERT-BUTYLOXYCARBONYL)(4-METHYLPHENYL)SULFONAMIDE 1-(6-METHYL[1,3]THIAZOLO[3,2-B][1,2,4]TRIAZOL-5-YL)ETHYL N-[(4-METHYLPHENYL)SULFONYL]CARBAMATE ETHYL 4-[2-(5-CHLORO-2-METHOXYBENZAMIDO)ETHYL]BENZENE SULFONAMIDE CARBAMATE 25,27-DIMETHOXY-26-(N-TOSYL)CARBOMOYLOXYCALIX[4]ARENE Tosular [5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL]METHYL N-[(4-METHYLPHENYL)SULFONYL]CARBAMATE

methyl tosylcarbamate

N-(4-Methylphenylsulfonyl)carbamic acid methyl ester

N-(Methoxycarbonyl)-p-toluenesulfonamide

N-(p-Tolylsulfonyl)carbamic acid methyl ester

N-Tosylcarbamic acid methyl ester

Einecs 238-411-4

(p-Tolylsulfonyl)carbaMic Acid Methyl Ester

[(4-Methylphenyl)sulfonyl]carbaMic Acid Methyl Ester

Methyl N-(p-toluenesulfonyl)carbaMate

Methyl N-(p-Tosyl)carbaMate

N-(p-Tosyl)carbaMic Acid Methyl Ester

CARBMIC ACID,N-[(4-METHYLPHENYL)SULFONYL]-,METHYL ESTER

Gliclazide Impurity 2 (Methyl Tosylcarbamate)

Carbamic acid, N-[(4-methylphenyl)sulfonyl]-, methyl ester

Gliclazide Impurity 19

methyl N-(4-methylphenyl)sulfonylcarbamate

METHYL (4-METHYLPHENYL)SULFONYLCARBAMATE

14437-03-7

Aromatics

Heterocycles

Impurities

Sulfur & Selenium Compounds