Description References
ChemicalBook > CAS DataBase List > 2-Amino-3-o-chlorobenzoyl-5-ethylthiophene

2-Amino-3-o-chlorobenzoyl-5-ethylthiophene

Description References
Product Name
2-Amino-3-o-chlorobenzoyl-5-ethylthiophene
CAS No.
50508-60-6
Chemical Name
2-Amino-3-o-chlorobenzoyl-5-ethylthiophene
Synonyms
2-Amino-3-o-chlorobenzoyl-5-ethylthiophene;2-Amino-5-ethyl-3-(2-chlorobenzoyl)thiophene;Methanone,(2-aMino-5-ethyl-3-thienyl)(2-chlorophenyl)-;(2-AMino-5-ethylthiophen-3-yl)(2-chlorophenyl)Methanone
CBNumber
CB9947146
Molecular Formula
C13H12ClNOS
Formula Weight
265.76
MOL File
50508-60-6.mol
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2-Amino-3-o-chlorobenzoyl-5-ethylthiophene Property

Boiling point:
454.8±45.0 °C(Predicted)
Density 
1.302
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMF: 10 mg/ml; DMSO: 5 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): insol
form 
a crystalline solid
pka
-1.81±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A603355
Product name
2-Amino-3-(2-chlorobenzoyl)-5-ethylthiophene
Packaging
100mg
Price
$60
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0011027
Product name
2-AMINO-3-O-CHLOROBENZOYL-5-ETHYLTHIOPHENE
Purity
95.00%
Packaging
5MG
Price
$500.2
Updated
2021/12/16
AK Scientific
Product number
Z5530
Product name
2-Amino-3-o-chlorobenzoyl-5-ethylthiophene
Packaging
1g
Price
$120
Updated
2021/12/16
Matrix Scientific
Product number
093974
Product name
(2-Amino-5-ethylthiophen-3-yl)-(2-chlorophenyl)methanone
Purity
95+%
Packaging
250mg
Price
$756
Updated
2021/12/16
Matrix Scientific
Product number
093974
Product name
(2-Amino-5-ethylthiophen-3-yl)-(2-chlorophenyl)methanone
Purity
95+%
Packaging
1g
Price
$1647
Updated
2021/12/16
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2-Amino-3-o-chlorobenzoyl-5-ethylthiophene Chemical Properties,Usage,Production

Description

2-Amino-3-o-chlorobenzoyl-5-ethylthiophene can be used as the raw material for the synthesis of Etizolam, which is an important sedative hypnotic and antidepressant drug. Its derivative, 2-amino-3-(p-chlorobenzoyl) thiophene scaffold has been widely employed as a pharmacophore for the identification of small molecules acting as allosteric modulators at the adenosine A1 receptor. 

References

Kai, Yong Mao, et al. "An Improved Synthesis of Etizolam." Journal of Southwest University of Science & Technology  (2014).
Romagnoli, R, et al. Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study..Longing for the end. Macmillan, 2015:185–204.

Chemical Properties

Yellow Solid

Uses

Used in the preparation of thienylamide derivatives as cholecystokinin inhibitors.

2-Amino-3-o-chlorobenzoyl-5-ethylthiophene Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-3-o-chlorobenzoyl-5-ethylthiophene Suppliers

Beijing Cooperate Pharmaceutical Co.,Ltd
Tel
+86-010-60279497 +86-15646567669
Fax
010-60279497
Email
sales01@cooperate-pharm.com
Country
China
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
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94657
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Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
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32321
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50
Shanghai Famo Bio-chemical Technology Company Ltd.
Tel
021-36680027 15821745250
Email
fengqiang@famobiotech.com
Country
China
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Shanghai Huikai Chemical Technology Co., Ltd.
Tel
021-61995394 18916691159
Email
chemicalsea@163.com
Country
China
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1972
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Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
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product02@bidepharm.com
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China
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ChemiK Co., Ltd.
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+86 574 8729 6330
Fax
+86 574 8729 7461
Email
info@chemik.com
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China
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Shanghai YuLue Chemical Co., Ltd.
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021-60345187 13671753212
Fax
021-34702061
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lzz841106@aliyun.com
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China
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Shanghai Synteam Biochem CO.,ltd
Tel
+86-021-58380978 +86-18017016373
Fax
021-58380978
Email
info@systeambc.com
Country
China
ProdList
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AN PharmaTech Co Ltd
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86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4891
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View Lastest Price from 2-Amino-3-o-chlorobenzoyl-5-ethylthiophene manufacturers

Career Henan Chemical Co
Product
2-Amino-3-o-chlorobenzoyl-5-ethylthiophene 50508-60-6
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-22

50508-60-6, 2-Amino-3-o-chlorobenzoyl-5-ethylthiophene Related Search:


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  • 2-Amino-5-ethyl-3-(2-chlorobenzoyl)thiophene
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  • (2-AMino-5-ethylthiophen-3-yl)(2-chlorophenyl)Methanone
  • 50508-60-6
  • Thiophene heterocycles