Crisnatol
Crisnatol Basic information
- Product Name:
- Crisnatol
- Synonyms:
-
- Crisnatol
- 2-(Chrysene-6-ylmethylamino)-2-methyl-1,3-propanediol
- 2-[(Chrysen-6-ylmethyl)amino]-2-methyl-1,3-propanediol
- 770U-82
- BW-A-770U
- 1,3-Propanediol, 2-((6-chrysenylmethyl)amino)-2-methyl-
- Crisnatol [inn]
- Crisnatolum
- CAS:
- 96389-68-3
- MF:
- C23H23NO2
- MW:
- 345.43
- Mol File:
- 96389-68-3.mol
Crisnatol Chemical Properties
- form
- Solid
- color
- White to off-white
Crisnatol Usage And Synthesis
Uses
Crisnatol (BWA770U) is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts[1][2][3].
in vivo
Crisnatol (25 mg/kg; p.o.; single dose) shows oral activity and shows stable metabolite profile extract of rat feces by autoradiography[2].
References
[1] Adams DJ. In vitro pharmacodynamic assay for cancer drug development: application to crisnatol, a new DNA intercalator. Cancer Res. 1989 Dec 1;49(23):6615-20. PMID:1676660
[2] Patel DK, et al. Metabolism of a novel antitumor agent, crisnatol, by a human hepatoma cell line, Hep G2, and hepatic microsomes. Characterization of metabolites. Biochem Pharmacol. 1991 Jul 5;42(2):337-46. DOI:10.1016/0006-2952(91)90721-g
[3] Patel DK, et al. Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat. Drug Metab Dispos. 1991 Mar-Apr;19(2):491-7. PMID:1676660
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