vinaxanthone
vinaxanthone Basic information
- Product Name:
- vinaxanthone
- Synonyms:
-
- vinaxanthone
- 9H-Xanthene-1-carboxylic acid, 5,7-diacetyl-6-(5-carboxy-6,7-dihydroxy-4-oxo-4H-1-benzopyran-3-yl)-2,3-dihydroxy-9-oxo-
- 5,7-Diacetyl-6-(5-carboxy-6,7-dihydroxy-4-oxo-4H-chromen-3-yl)-2,3-dihydroxy-9-oxo-9H-xanthene-1-carboxylic acid
- CAS:
- 133293-89-7
- MF:
- C28H16O14
- MW:
- 576.42
- Mol File:
- 133293-89-7.mol
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vinaxanthone Chemical Properties
- form
- Solid
- color
- Light yellow to yellow
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vinaxanthone Usage And Synthesis
Uses
Vinaxanthone is used in the pharmaceutical composition containing xanthone compound SM-?345431 for treating cerebral infarction.
in vivo
Vinaxanthone (SM-345431) (0.1 mg/mL, Subconjunctival injections, every 2 days, 3 weeks) accelerates peripheral nerve regeneration and sensitivity in a murine corneal transplantation model[4].
Vinaxanthone (SEMA3A-I) (20 μg, i.p.) protects from Doxorubicin (HY-15142A)-induced podocyte injury through an anti-apoptosis mechanism in mouse model of Doxorubicin (HY-15142A)-induced podocytopathy[5].
| Animal Model: | murine corneal transplantation model[4] |
| Dosage: | 0.1 mg/mL |
| Administration: | Subconjunctival injections, every 2 days, 3 weeks |
| Result: | Showed significantly higher nerve growth. Improved the corneal sensitivity. |
| Animal Model: | mouse model of Doxorubicin (10 mg/kg)-induced podocytopathy[5] |
| Dosage: | 20 μg |
| Administration: | Intraperitoneal injection (i.p.), every day |
| Result: | Improved the expression of nephrin. Reduced podocytopathy and tubular casts. Detected rarely TUNEL-positive cells in the Dox + Vinaxanthone group. Had fewer p-c-Jun-positive cells in the Dox + Vinaxanthone group. |
vinaxanthoneSupplier
BOC Sciences
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
Bide Pharmatech Ltd.
- Tel
- 400-164-7117 13681763483
- product02@bidepharm.com
Chengdu Novel Biomedical Co., Ltd.
- Tel
- 028-85255396 18302801538
- cdnovell@163.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
Shanghai Tachizaki Biomedical Research Center
- Tel
- 18014399201
- sales@chemlab-tachizaki.com
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