Ro 41-5253 Chemical Properties

storage temp. 

-20°C

solubility 

DMSO: soluble20mg/mL, clear

form 

powder

color 

white to beige

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Safety Information

WGK Germany 

3

Ro 41-5253 Usage And Synthesis

Description

Ro 41-5253 (144092-31-9) is a selective RARα antagonist.1?Binds RARα without inducing transcription or influencing RAR/RXR heterodimerization and DNA binding.2?Ro 415253 inhibits proliferation and induces apoptosis in a variety of cell lines/types. Cell Permeable.

Uses

Ro 415253 is a retinoic acid receptor antagonists, a promising starting point for antimetastatic therapies.

Definition

ChEBI: A thiochromane that is 3,4-dihydro-2H-1-benzothiopyran S,S-dioxide in which the hydrogens at position 4 are both replaced by methyl groups, the hydrogens at position 7 is replaced by a heptyloxy group, w ile the hydrogen at position 6 is replaced by a 1-phenylprop-1-en-2-yl group, the phenyl group of which is substituted at the para position by a carboxy group. It is a selective antagonist for retinoic acid receptor alpha.

References

1) Apfel?et al. (1992),?A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects; Proc. Natl. Acad. Sci. USA,?89?7129 2) Toma?et al. (1998),?RARα antagonist Ro 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines; Int. J. Cancer,?78?86

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