ETAZOLATE Chemical Properties

Melting point:

193-194°C

Boiling point:

427.6±55.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

H₂O: >20 mg/mL Solutions should be freshly prepared.

pka

9.94±0.70(Predicted)

form 

solid

color 

white

CAS DataBase Reference

51022-77-6

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

ETAZOLATE Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

PDE inhibitor

Uses

An inhibitor of phosphodiesterase IV, about 8 times more active for cAMP than cGMP.

Uses

Etazolate Hydrochloride is an acyclic nucleotide phosphodiesterase 4 inhibitor, which also exhibits antidepressant-like activity in acute and chronic mouse and rat model of depression.

Definition

ChEBI: Etazolate is a pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties. It has a role as a neuroprotective agent, an antipsychotic agent, a phosphodiesterase IV inhibitor, an anxiolytic drug, an antidepressant, an alpha-secretase activator and a GABA agent. It is a hydrazone, an ethyl ester and a pyrazolopyridine.

Biological Activity

Phosphodiesterase inhibitor, selective for PDE4 (IC 50 = 2.0 μ M).

ETAZOLATE(51022-77-6)Related Product Information

• 4-AMINO-3-FORMYLPYRIDINE
• 4-AMINO-3-FORMYLPYRIDINE HCL
• 4-HYDRAZINOPYRIDINE HYDROCHLORIDE
• 4-Amino-3-pyridinecarboxylic acid
• 1H-PYRAZOLO[3,4-B]PYRIDIN-4-AMINE
• (4-AMINO-PYRIDIN-3-YL)-METHANOL
• Methyl 4-aminopyridine-3-carboxylate
• 3-Methyl-4-aminopyridine
• Pyridine, 4-hydrazino-3-methyl- (9CI)
• 1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID
• 4-AMINOPYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
• ETAZOLATE
• 4-hydrazinylpyridine hydrochloride