TIN PROTOPORPHYRIN IX DICHLORIDE Chemical Properties

storage temp. 

Store at RT

solubility 

Soluble to 25 mM in 1eq. NaOH and to 5 mM in DMSO

form 

Dark red to violet solid.

TIN PROTOPORPHYRIN IX DICHLORIDE Usage And Synthesis

Uses

Tin Protoporphyrin IX Dichloride is a selective inhibitor of heme oxygenase.

Uses

Heme oxygenase (HO) converts protoheme to biliverdin, which in turn is enzymatically metabolized to bilirubin . While HO-2 is constitutively expressed, HO-1 can be induced by its heme substrate as well as by heavy metals, oxidizing agents, and other environmental stresses. TIN PROTOPORPHYRIN IX DICHLORIDE(SnPPIX) is a synthetic heme analog that selectively inhibits HO-1 (Ki = 11 nM) over HO-2 (IC50 = 7.5 μM). It also weakly inhibits endothelial nitric oxide synthase and soluble guanylyl cyclase (IC50s = 35 and 30 nM, respectively). SnPPIX prevents hyperbilirubinemia in neonates by blocking HO-1 activity that increases postnatally. It is rapidly cleared from plasma and persists in certain tissues, including kidney, liver, and spleen. SnPPIX is commonly used as a tool to study the role of HO-1 activity in cells and in animals.[Cayman Chemical]

TIN PROTOPORPHYRIN IX DICHLORIDE(14325-05-4)Related Product Information

• PROTOPORPHYRINATO ZINC
• Protoporphyrin IX
• Stannous chloride dihydrate
• HEPTA-4,6-DIENOIC ACID
• TIN PROTOPORPHYRIN IX DICHLORIDE