Lithium dodecyl sulfate Chemical Properties

Boiling point:

199℃[at 101 325 Pa]

Density 

1.168[at 20℃]

vapor pressure 

6.5Pa at 20℃

storage temp. 

Inert atmosphere,Room Temperature

solubility 

H₂O: 0.1 M at 20 °C, clear, colorless

form 

Shiny Crystalline Flakes or Powder

color 

White

PH

pH(0.25mol/l, 25℃) : 5.0～10.5

Appearance

White to Almost white powder to crystal.

Water Solubility 

Soluble in water.

BRN 

5186718

Stability:

Stable. Incompatible with strong oxidizing agents.

InChI

InChI=1S/C12H26O4S.Li/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1

InChIKey

YFVGRULMIQXYNE-UHFFFAOYSA-M

SMILES

C(COS([O-])(=O)=O)CCCCCCCCCC.[Li+]

CAS DataBase Reference

2044-56-6(CAS DataBase Reference)

EPA Substance Registry System

Sulfuric acid, monododecyl ester, lithium salt (2044-56-6)

Absorption

≤0.05 at 260nm (3% solution)
≤0.05 at 280nm (3% solution)

Safety Information

Hazard Codes 

Xi,C,F

Risk Statements 

36/37/38-34-20/21/22-15-14-11-41-37/38

Safety Statements 

26-36-45-43-36/37/39-16-7/8-3/7/9-39

RIDADR 

UN1325 - class 4.1 - PG 3 - Flammable solids, organic, n.o.s., HI: all

WGK Germany 

3

F 

3

TSCA 

Yes

HazardClass 

4.1

HS Code 

29209010

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Lithium dodecyl sulfate Usage And Synthesis

Description

Lithium dodecyl sulfate (LDS) is an anionic detergent and surfactant that is frequently used in electrophoresis and chromatography. LDS may be substituted for sodium dodecyl sulfate (SDS) in electrophoresis under cold conditions. The use of LDS in micellar electrokinetic chromatography has been extensively studied. A report has been published on the partition equilibria of LDS between water and bilayer membranes. LDS has been utilized in protein electrophoresis and proteomics studies. The three-dimensional structure of the amyloid β-protein fragment 25-35 has been investigated in LDS micelles by two-dimensional 1HNMR. LDS has been used to induce changes in protein conformation.

Chemical Properties

Lithium dodecyl sulfate is a white, shiny crystalline powder or flake, soluble in organic solvents such as alcohols, ethers, and hydrocarbons, but only slightly soluble in water. It exhibits good thermal stability and remains stable at room temperature. As an anionic surfactant, it demonstrates excellent surface activity.

Uses

Lithium dodecyl sulfate has been used as a component of lysis buffer.

Uses

Anionic detergent that may be used in place of SDS for electrophoresis in cold conditions.

Flammability and Explosibility

Flammable

Purification Methods

Recrystallise this detergent twice from absolute EtOH and dry it under vacuum. Critical Micellar Concentration (CMC) in H2O is 8.77 x 10-3M. [Mukerjee et al. J Phys Chem 71 4166 1967, Mysels & Dulin J Colloid Sci 10 461 1955, Beilstein 1 IV 1847.]

Precautions

In general, autoclaved lauryl sulfate solutions undergo hydrolysis to yield lauryl alcohol, which precipitates from solution, and sulfuric acid, which decreases the solution pH. It is not advised to autoclave lauryl sulfate solutions.

References

[1] ELISABET FUGUET. Solute−Solvent Interactions in Micellar Electrokinetic Chromatography. 6. Optimization of the Selectivity of Lithium Dodecyl Sulfate−Lithium Perfluorooctanesulfonate Mixed Micellar Buffers[J]. Analytical Chemistry, 2002, 74 17: 4447-4455. DOI:10.1021/ac0201530.
[2] M D TRONE. Characterization of chemical selectivity in micellar electrokinetic chromatography. VI. Effects of surfactant counter-ion.[J]. Journal of Chromatography A, 2000, 888 1-2: 229-240. DOI:10.1016/s0021-9673(00)00515-x.
[3] GARY H. PERDEW Daniel P S Henry W Schaup. The use of a zwitterionic detergent in two-dimensional gel electrophoresis of trout liver microsomes[J]. Analytical biochemistry, 1983, 135 2: Pages 453-455. DOI:10.1016/0003-2697(83)90711-X.
[4] SHINJI KONDOU. Concentrated Lithium Dodecyl Sulfate Aqueous Electrolytes: Utilizing Self-Assembly and Interfacial Adsorption for Aqueous Li-ion Batteries[J]. ChemElectroChem, 2022, 9 20. DOI:10.1002/celc.202200870.

Lithium dodecyl sulfate(2044-56-6)Related Product Information

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• Dodecyltrimethylammonium chloride
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• Tetrapropenylsuccinic Anhydride (mixture of branched chain isomers)
• Lithium hydride
• Lithium
• Lithium dodecyl sulfate
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