QUIN 2-AM
QUIN 2-AM Basic information
- Product Name:
- QUIN 2-AM
- Synonyms:
-
- QUIN 2-AM
- QUIN-2 TETRAACETOXYMETHYL ESTER
- 2-[(2-AMINO-5-METHYLPHENOXY)METHYL]-6-METHOXY-8-AMINO-QUINOLINE-N,N,N',N'-TETRAACETIC ACID TETRAKIS(ACETOXYMETHYL-ESTER)
- 2-[[2-BIS(CARBOXYMETHYL)AMINO-5-METHYLPHENOXY]-METHYL]-6-METHOXY-8-BIS(CARBOXYMETHYL)AMINOQUINOLINE TETRAKIS(ACETOXYMETHYL) ESTER
- quin2-acetoxymethylester
- 2-[(2-amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-n,n,n',n'-tetraacetic acid tetrakis(acetoxymethyl ester)
- 2-[(2-Amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-N,N,Nμ,Nμ-tetraacetic acid tetrakis(acetoxymethyl ester), 2-{[2-Bis(carboxymethyl)amino-5-methylphenoxy]-methyl}-6-methoxy-8-bis(carboxymethyl)aminoquinoline tetrakis(acetoxymethyl) ester
- 8-Amino-2-[(2-amino-5-methylphenoxy)-methyl]-6-methoxyquinoline-N,N,N',N'-tetraacetic acid
- CAS:
- 83104-85-2
- MF:
- C38H43N3O18
- MW:
- 829.76
- Product Categories:
-
- Quinoline
- Mol File:
- 83104-85-2.mol
QUIN 2-AM Chemical Properties
- Density
- 1.360
- Flash point:
- 113 °C
- storage temp.
- −20°C
- solubility
- DMSO: soluble
- form
- A solid
- λmax
- 348 nm
- Biological Applications
- Calcium indicator
MSDS
- Language:English Provider:SigmaAldrich
QUIN 2-AM Usage And Synthesis
Description
Quin-2 AM is a cell-permeant acetoxymethyl ester of the high affinity fluorescent calcium indicator quin-2 . As quin-2 AM enters cells, it is hydrolyzed by intracellular esterases to produce quin-2. Quin-2 binds calcium with a Kd value of 115 nM. It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH. High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells. Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation and emission maxima for quin-2 are 339 and 492 nm, respectively.
Uses
Fluorescent probe for measurement of calcium in biological systems and for selected divalent cations.
Uses
2-[(2-Amino-5-methylphenoxy)methyl]-6-methoxy-8-aminoquinoline-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester)
Uses
Quin 2-AM is a cell permeable fluorescent probe for Ca2+ that gives a large shift in the UV absorption spectrum and a 20-fold increase in fluorescence upon Ca2+ binding.
QUIN 2-AMSupplier
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QUIN 2-AM(83104-85-2)Related Product Information
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- Fluo 3-AM
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- 3-ETHYLAMINOPHENOL
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- N,N-DIMETHYLGLYCINE METHYL ESTER
- Iminodiacetic acid
- N-Ethyl-N-hydroxyethylaniline
- 3-METHOXY-N-METHYLANILINE
- 2-METHYLAMINOPHENOL
- N,N-BIS(2-HYDROXYETHYL)-3-METHOXYANILINE
- 8-Aminoquinaldine