Notoginsenoside R1 Chemical Properties

Melting point:

215～217℃

Boiling point:

1010.5±65.0 °C(Predicted)

Density 

1.39±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

H2O: soluble1mg/mL, clear, colorless

pka

12.85±0.70(Predicted)

form 

powder

color 

white to off-white

InChIKey

LLPWNQMSUYAGQI-OOSPGMBYSA-N

LogP

1.354 (est)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29389090

Hazardous Substances Data

80418-24-2(Hazardous Substances Data)

Notoginsenoside R1 Usage And Synthesis

Description

Notoginsenoside R1 is a ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position. It is a beta-D-glucoside, a 12beta-hydroxy steroid, a 3beta-hydroxy steroid, a disaccharide derivative, a ginsenoside, a tetracyclic triterpenoid and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane.

Uses

Notoginsenoside R1 is an active ingredient isolated from Panax notoginseng that induces tissue-type plasminogen activator synthesis in cultured human umbilical vein endothelial cells.

Application

Notoginsenoside R1 has a role as a plant metabolite, an antioxidant, a neuroprotective agent, an apoptosis inducer and a phytoestrogen. 

Uses

Notoginsenoside R1 acts as an anti-inflammatory agent, inhibiting TNF-α induced PAI-1 production in aortic smooth muscle cells in humans.

Definition

ChEBI: Notoginsenoside R1 is a ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position. It has a role as a plant metabolite, an antioxidant, a neuroprotective agent, an apoptosis inducer and a phytoestrogen. It is a beta-D-glucoside, a 12beta-hydroxy steroid, a 3beta-hydroxy steroid, a disaccharide derivative, a ginsenoside, a tetracyclic triterpenoid and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane.

Notoginsenoside R1(80418-24-2)Related Product Information

• PANAX NOTOGINSENOSIDES
• Saponin
• Ginseng extract
• Dioscin
• Escin
• TRIBULOSIDE
• Notoginsenoside Ft1
• Notoginseng triterpenes
• Notoginsenoside R2
• 20(R)-Notoginsenoside R2
• Notoginsenoside FP2
• NotoginsenosideFc
• GYPENOSIDE IX
• Notoginsenoside Fa
• Notoginsenoside S
• 3,3,5,5-TETRAMETHYLCYCLOHEXANOL
• GINSENOSIDEF1
• Ginsenoside Rg1