L-QUEBRACHITOL
L-QUEBRACHITOL Basic information
- Product Name:
- L-QUEBRACHITOL
- Synonyms:
-
- L-CHIRO-INOSITOL 2-METHYL ETHER
- L-QUEBRACHITOL
- QUEBRACHITOL
- 1L-2-O-METHYL-CHIRO-INOSITOL
- 2-O-METHYL-L-CHIRO-INOSITOL
- 2-O-METHYL-1,2,4/3,5,6-HEXAHYDROXYCYCLOHEXANE
- 3-O-METHYL-L-CHIRO-INOSITOL
- (1R,2S,3S,4S,5R,6R)-6-Methoxycyclohexane-1,2,3,4,5-pentaol
- CAS:
- 642-38-6
- MF:
- C7H14O6
- MW:
- 194.18
- Product Categories:
-
- Miscellaneous Natural Products
- Mol File:
- 642-38-6.mol
L-QUEBRACHITOL Chemical Properties
- Melting point:
- 190-198 °C
- Boiling point:
- 250.62°C (rough estimate)
- Density
- 1.56±0.1 g/cm3 (20 ºC 760 Torr)
- refractive index
- 1.572
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO (Slightly), Water (Sparingly)
- form
- Solid
- pka
- 12.98±0.70(Predicted)
- color
- White to Off-White
- LogP
- -0.740 (est)
- CAS DataBase Reference
- 642-38-6(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 24/25-36-26
MSDS
- Language:English Provider:ACROS
L-QUEBRACHITOL Usage And Synthesis
Chemical Properties
white to off-white powder
Uses
L-Quebrachitol is a methoxy analog of inositol that can be isolated from plants. L-Quebrachitol has free-radical scavenging, gastroprotection, anti-platelet aggregation and anti-diabetic activity. L-Quebrachitol promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway[1][2][3].
Definition
ChEBI: L-Quebrachitol is a member of cyclohexanols.
in vivo
L-Quebrachitol (125 mg/kg) significantly reduces weight gain, increases bone mineral density and bone calcium content of ovariectomized rats[2].
References
[1] Yodthong T, et al. l-Quebrachitol Promotes the Proliferation, Differentiation, and Mineralization of MC3T3-E1 Cells: Involvement of the BMP-2/Runx2/MAPK/Wnt/β-Catenin Signaling Pathway. Molecules. 2018 Nov 26;23(12). DOI:10.3390/molecules23123086
[2] Li Y, et al. L-quebrachitol extracted from industrial rubber serum: a study on its antioxidant activities and bone mineral density enhancing functions[J]. Industrial Crops and Products, 2023, 201: 116943.
[3] Mu Y, et al. Sea buckthorn leaf l-quebrachitol extract for improved glucose and lipid metabolism in insulin resistant HepG2 Cells[J]. Bioresources, 2022, 17(1): 527.
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L-QUEBRACHITOL(642-38-6)Related Product Information
- GLUCOTROPAEOLIN
- Xanthiazone
- Z-LIGUSTILIDE
- Camphene
- Hydroxycitric acid
- Isorhamnetin
- menisdaurin
- 4-Methoxybenzoic acid 2-(4-hydroxyphenyl)ethyl ester
- ALPHA-CARYOPHYLLENE
- Xylitol
- L-(-)-CHIRO-INOSITOL
- L-QUEBRACHITOL
- HEXA(2-CYANOETHOXY) CYCLOHEXANE
- 1,2:3,4-DI-O-CYCLOHEXYLIDENE-5-O-METHYL-L-CHIRO-INOSITOL
- L-CHIRO-INOSITOL DIACETONIDE
- INOSITOL HEXAACETATE
- QUEBRACHITOL DIACETONIDE
- 1,2:5,6-BIS-O-(1-METHYLETHYLIDENE)-1L-CHIRO-INOSITOL