(R)-(+)-HA-966
(R)-(+)-HA-966 Basic information
- Product Name:
- (R)-(+)-HA-966
- Synonyms:
-
- R(+)-HA-966 R(+)-3-AMINO-1-HYDROX
- (R)-(+)-HA-966
- R(+)-3-AMINO-1-HYDROXY-2-PYRROLIDINONE
- (R)-(+)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE
- Zinc03791818
- (3R)-3-Amino-1-hydroxy-2-pyrrolidinone
- (R)-3-amino-1-hydroxypyrrolidin-2-one 2,2,2-trifluoroacetate
- 2-Pyrrolidinone, 3-amino-1-hydroxy-, (3R)-
- CAS:
- 123931-04-4
- MF:
- C4H8N2O2
- MW:
- 116.12
- Product Categories:
-
- Glutamate receptor
- Mol File:
- 123931-04-4.mol
(R)-(+)-HA-966 Chemical Properties
- Melting point:
- 166℃
- Boiling point:
- 258.6±50.0 °C(Predicted)
- Density
- 1.436±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at RT
- solubility
- H2O: soluble
- form
- solid
- pka
- 7.19±0.20(Predicted)
- color
- white
- optical activity
- [α]22/D +103°, c = 1 in H2O(lit.)
- Water Solubility
- Soluble to 100 mM in water
MSDS
- Language:English Provider:SigmaAldrich
(R)-(+)-HA-966 Usage And Synthesis
Uses
(R)-(+)-HA-966 is an antagonist/partial agonist at the glycine site of the NMDA receptor.
Biological Activity
Antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .
in vivo
(R)-(+)-HA-966 ((+)-HA-966; 10 mg/kg; IV) significantly attenuates the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA (125, 250, 500, and 1000 mg/kg; i.v.)[3].
(+)-HA-966 (30, 100 mg/kg; IP) dose-dependently blocks the enhancement of dopamine synthesis induced in the nucleus accumbens by amphetamine, but is without effect on the increase in dopamine synthesis in the striatum in male BKTO mice (20-30g)[1].
| Animal Model: | Sprague-Dawley rats (11 to 12 weeks old)[3] |
| Dosage: | 10 mg/kg |
| Administration: | IV |
| Result: | Significantly attenuated the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA. |
IC 50
NMDA Receptor
storage
Desiccate at RT
(R)-(+)-HA-966Supplier
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
- Tel
- 13526569071
- sales@leadmedpharm.com
- Tel
- 86-0571-85151182
- Tel
- 888-539-0666
- info@emmx.com
- Tel
- 0371-56787280 13137706083
- m18539565376@163.com