2,4-Dichlorophenylacetonitrile Chemical Properties

Melting point:

58-61 °C (lit.)

Boiling point:

306.06°C (rough estimate)

Density 

1.4274 (rough estimate)

refractive index 

1.5690 (estimate)

Flash point:

176 °C

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

color 

White to Light yellow to Light orange

BRN 

2047688

Exposure limits

NIOSH: IDLH 25 mg/m3

CAS DataBase Reference

6306-60-1(CAS DataBase Reference)

NIST Chemistry Reference

Benzeneacetonitrile, 2,4-dichloro-(6306-60-1)

EPA Substance Registry System

(2,4-Dichlorophenyl)acetonitrile (6306-60-1)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-36/37/39

RIDADR 

3276

WGK Germany 

1

HazardClass 

6.1

PackingGroup 

III

HS Code 

29269090

MSDS

• Language:English Provider:2,4-Dichlorophenylacetonitrile
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,4-Dichlorophenylacetonitrile Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

2,4-Dichlorophenylacetonitrile was used in the synthesis of 2,4-dichloromandelic acid.

Synthesis

General method: 2,4-dichlorobenzyl chloride (1.0 mmol) was mixed with sodium cyanide (2 mmol) in deionized water (5 mL) and polyethylene glycol modified diisocyanate (PEG-MDIL, 0.2 g) was added. The reaction suspension was placed under reflux conditions and the reaction mixture was stirred using a magnetic stirrer for the reaction time referred to in Table 2.After completion of the reaction, the mixture was extracted with ether (2 × 10 mL). The organic extracts were combined, dried with anhydrous calcium chloride and subsequently concentrated under reduced pressure. By this method, the target product 2,4-dichlorophenylacetonitrile was obtained in good to excellent isolated yields (see Scheme 3).

References

[1] Organic Preparations and Procedures International, 2011, vol. 43, # 3, p. 285 - 291
[2] Journal of Molecular Liquids, 2015, vol. 202, p. 34 - 39
[3] Journal of Molecular Catalysis A: Chemical, 2012, vol. 365, p. 80 - 86
[4] Applied Organometallic Chemistry, 2018, vol. 32, # 2,
[5] Catalysis Communications, 2012, vol. 18, p. 102 - 105

2,4-Dichlorophenylacetonitrile(6306-60-1)Related Product Information

• 2,4-Dichlorophenylacetonitrile
• 2-(3,4-DICHLOROPHENYL)ACETONITRILE,3,4-DICHLOROPHENYLACETONITRILE
• 2,3-DICHLOROPHENYLACETONITRILE
• 2,6-DICHLOROPHENYLACETONITRILE
• Chlorobenzene
• 1-(2,4-DICHLOROPHENYL)-1-CYCLOPROPYL CYANIDE
• 2-(2,4-DICHLOROPHENYL)-3-(DIMETHYLAMINO)ACRYLONITRILE
• 2-(2-CYANO-3-FLUOROPHENYL)-2-(2,4-DICHLOROPHENYL)ACETONITRILE
• 2-(6-CHLORO-3-PYRIDAZINYL)-2-(2,4-DICHLOROPHENYL)ACETONITRILE
• 2-(4-BENZOYLPHENYL)-2-(2,4-DICHLOROPHENYL)ACETONITRILE
• 2,4-DICHLORO-5-FLUOROPHENYLACETONITRILE
• 2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]SULFANYL)-2-(2,4-DICHLOROPHENYL)ACETONITRILE
• 2-(6-CHLORO-3-PYRIDAZINYL)-2-(2,6-DICHLOROPHENYL)ACETONITRILE
• 2-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-2-(2,6-DICHLOROPHENYL)ACETONITRILE,2-[3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YL]-2-(2,6-DICHLOROPHENYL)ACETONITRILE
• Pentachloromandelonitrile
• SALOR-INT L153303-1EA
• 2-(2,4-DICHLOROPHENYL)-2-[6-(1-PYRROLIDINYL)-3-PYRIDAZINYL]ACETONITRILE
• 2-(6-[(4-CHLOROPHENYL)SULFANYL]-3-PYRIDAZINYL)-2-(2,4-DICHLOROPHENYL)ACETONITRILE