2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Chemical Properties

Melting point:

161.8-163 °C

Boiling point:

459.9±28.0 °C(Predicted)

Density 

1.44±0.1 g/cm3(Predicted)

vapor pressure 

0.004Pa at 25℃

storage temp. 

2-8°C

solubility 

DMSO: 13 mg/mL

pka

2.96±0.40(Predicted)

form 

solid

color 

white

Water Solubility 

5.7g/L at 20℃

InChIKey

UQDVRVNMIJAGRK-UHFFFAOYSA-N

LogP

0.49 at 20℃

CAS DataBase Reference

27277-00-5(CAS DataBase Reference)

EPA Substance Registry System

2-Amino-4,5-dihydro-6-methyl-4-propyl-s-triazolo-(1,5-a)-pyrimidin-5-one (27277-00-5)

Safety Information

RIDADR 

2811

WGK Germany 

1

HazardClass 

6.1(b)

PackingGroup 

III

MSDS

• Language:English Provider:SigmaAldrich

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one Usage And Synthesis

Uses

ICI 63197 is a specific cAMP phosphodiesterase (PDE) inhibitor. It is potent in anatagonizing reserpine-induced hypothermia. potent PDE4 inhibitor.

Definition

ChEBI: 2-amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one is a member of triazolopyrimidines.

Flammability and Explosibility

Not classified

Biological Activity

Potent phosphodiesterase (PDE) 4 inhibitor (IC 50 = 35 nM for inhibition of [ 3 H]-rolipram binding to rat brain). Antidepressant following systemic administration in vivo .

Biochem/physiol Actions

Phosphodiesterase IV (PDE 4) inhibitor

storage

+4°C

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one(27277-00-5)Related Product Information

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• 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-one