Basic information Safety Supplier Related

AMASTATIN HYDROCHLORIDE

Basic information Safety Supplier Related

AMASTATIN HYDROCHLORIDE Basic information

Product Name:
AMASTATIN HYDROCHLORIDE
Synonyms:
  • [(2S,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOYL]-VAL-VAL-ASP HYDROCHLORIDE
  • (2S,3R)-[3-AMINO-2-HYDROXY-5-METHYLHEXANOYL]-VAL-VAL-ASP-OH HCL
  • AMASTATIN
  • AMASTATIN HCL
  • AMASTATIN HYDROCHLORIDE
  • AMASTATIN HYDROCHLORIDE HYDRATE
  • H-(2S,3R)-AHMH-VAL-VAL-ASP-OH HCL
  • N((2S 3R)3-AMINO-2-HXY-5-ME.HEXANOYL)-L&
CAS:
100938-10-1
MF:
C21H39ClN4O8
MW:
511.01
EINECS:
999-999-2
Product Categories:
  • peptides
  • inhibitor
  • Pepetides
Mol File:
100938-10-1.mol
More
Less

AMASTATIN HYDROCHLORIDE Chemical Properties

Melting point:
202-205 °C
storage temp. 
-20°C
solubility 
methanol: 5 mg/mL, clear, colorless
form 
White to off-white powder.
color 
White to off-white
BRN 
8888370
More
Less

Safety Information

WGK Germany 
3
10
HS Code 
2924190090
More
Less

AMASTATIN HYDROCHLORIDE Usage And Synthesis

Uses

Amastatin is a slow, tight binding, competitive aminopeptidase (AP) inhibitor, first described as an inhibitor of human serum AP-A (glutamyl AP; IC50 = 0.54 μg/ml) but not of AP-B (arginine AP). It also inhibits AP-N (AP-M, alanyl AP; Ki = 20-200 nM), leucyl-cystinyl AP (Ki = 20-220 nM), and endoplasmic reticulum AP 1 (Ki = 41.8 μM). Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin, or thermolysin.[Cayman Chemical]

General Description

Chemical structure: peptide

Biochem/physiol Actions

It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts angiotensin II to angiotensin III. Potentiates the CNS effects of vasopressin and oxytocin in vivo.Effective concentration: 1-10 μM.

storage

+4°C

AMASTATIN HYDROCHLORIDESupplier

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
Alabiochem Tech.Co., Ltd.
Tel
0512-58900862 400-0707518
Email
sales@alabiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com