AMASTATIN HYDROCHLORIDE Chemical Properties

Melting point:

202-205 °C

storage temp. 

-20°C

solubility 

methanol: 5 mg/mL, clear, colorless

form 

White to off-white powder.

color 

White to off-white

BRN 

8888370

Safety Information

WGK Germany 

3

F 

10

HS Code 

2924190090

AMASTATIN HYDROCHLORIDE Usage And Synthesis

Uses

Amastatin is a slow, tight binding, competitive aminopeptidase (AP) inhibitor, first described as an inhibitor of human serum AP-A (glutamyl AP; IC50 = 0.54 μg/ml) but not of AP-B (arginine AP). It also inhibits AP-N (AP-M, alanyl AP; Ki = 20-200 nM), leucyl-cystinyl AP (Ki = 20-220 nM), and endoplasmic reticulum AP 1 (Ki = 41.8 μM). Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin, or thermolysin.[Cayman Chemical]

General Description

Chemical structure: peptide

Biochem/physiol Actions

It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts angiotensin II to angiotensin III. Potentiates the CNS effects of vasopressin and oxytocin in vivo.Effective concentration: 1-10 μM.

storage

+4°C

AMASTATIN HYDROCHLORIDE(100938-10-1)Related Product Information

• N-(2-AMINOETHYL)-L-ASPARTIC ACID
• GLYCYLGLYCINE HYDROCHLORIDE
• L-Homoserine
• L-Aspartic acid hydrochloride
• D-Leucinol
• H-VAL-NH2 HCL
• 1,3-Diamino-2-propanol
• H-BETA-ALA-NH2 HCL
• (R)-HOMO-BETA-ALANINE HYDROCHLORIDE
• H-VAL-ASP-OH
• AC-VAL-NHME
• H-ALA-ALA-NH2 HCL
• AC-VAD-CHO
• (S)-(-)-LACTAMIDE
• H-VAL-BETA-ALA-OH
• BETA-HOMOALANINE HYDROCHLORIDE
• AMASTATIN,AMASTATIN, STREPTOMYCES SPECIES
• H-ALA-VAL-NH2 HCL