Basic information Safety Supplier Related

MG-115

Basic information Safety Supplier Related

MG-115 Basic information

Product Name:
MG-115
Synonyms:
  • PROTEASOME INHIBITOR MG-115
  • N-CBZ-LEU-LEU-NORVALINAL
  • MG-115
  • Z-LL-NVA-CHO
  • Z-LEU-LEU-NVA-ALDEHYDE
  • Z-LEU-LEU-NVA-CHO
  • Z-LEU-LEU-NVA-H
  • Z-LEU-LEU-NVA-H (ALDEHYDE)
CAS:
133407-86-0
MF:
C25H39N3O5
MW:
461.59
Product Categories:
  • Calpain and Lysosomal Proteases
  • Proteasome Inhibitors
  • Aldehydes
  • and Substrates
  • Application Index
  • Bioactive Small Molecules
  • Biochemicals and Reagents
  • Building Blocks
  • C13-C60
  • Calpain and Proteasome Inhibitors
  • Carbonyl Compounds
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Cell Signaling Enzymes
  • Chemical Synthesis
  • Endoplasmic Reticulum Stress
  • Enzymes
  • Inhibitors
  • Intracellular Protein Degradation
  • Nitric Oxide and Cell Stress
  • Organic Building Blocks
  • Proteasome
  • Proteasomes
  • Z
  • ProteasomeInhibitors
  • peptides
Mol File:
133407-86-0.mol
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MG-115 Chemical Properties

Boiling point:
678.8±55.0 °C(Predicted)
Density 
1.082±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble
form 
powder
pka
11.14±0.46(Predicted)
color 
white
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Safety Information

WGK Germany 
3

MSDS

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MG-115 Usage And Synthesis

Description

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.

Uses

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.[Cayman Chemical]

Uses

MG-115 is a compound that inhibits the chymotrypsin-like activity of the proteasome.

Definition

ChEBI: N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamic acid (phenylmethyl) ester is a peptide.

General Description

Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively).

Biochem/physiol Actions

Product does not compete with ATP.

References

1. involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome. imamura, t., haruta, t., takata, y., usui, i., iwata, m., ishihara, h., ishiki, m., ishibashi, o., ueno, e., sasaoka, t., kobayashi, m. j. biol. chem. (1998)

MG-115Supplier

Alabiochem Tech.Co., Ltd.
Tel
0512-58900862 400-0707518
Email
sales@alabiochem.com
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Email
isunpharm@qq.com
ApexBio Technology LLC
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+1-832-696-8203
Email
info@apexbt.com
Sigma-Aldrich
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021-61415566 800-8193336
Email
orderCN@merckgroup.com
Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
Email
info@efebio.com