GAMMA-SECRETASE INHIBITOR
GAMMA-SECRETASE INHIBITOR Basic information
- Product Name:
- GAMMA-SECRETASE INHIBITOR
- Synonyms:
-
- Z-LEU-LEU-NLE-ALDEHYDE
- Z-LEU-LEU-NLE-CHO
- Z-LLNLE-CHO
- GAMMA-SECRETASE INHIBITOR
- GAMMA-SECRETASE INHIBITOR I
- Cbz-leucinyl-leucinyl-norleucinal
- γ-Secretase Inhibitor I
- L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formylpentyl]-
- CAS:
- 133407-83-7
- MF:
- C26H41N3O5
- MW:
- 475.62
- Product Categories:
-
- Alzheimers and Neurodegenerative Disease Research
- gamma SecretaseNeurobiology
- Neurodegenerative Disease Peptides
- Other Alzheimer Peptides
- Protease Inhibitor Specificity Index
- Protease Inhibitors
- R to
- γSecretaseEnzyme Inhibitors by Enzyme
- OtherNeuropeptides
- Z-Leu-Leu-Nle-CHO
- Pepetides
- peptides
- Mol File:
- 133407-83-7.mol
More
Less
GAMMA-SECRETASE INHIBITOR Chemical Properties
- storage temp.
- −20°C
- solubility
- DMSO: soluble
- form
- powder
- color
- White to off-white
- Sensitive
- Hygroscopic
MSDS
- Language:English Provider:SigmaAldrich
More
Less
GAMMA-SECRETASE INHIBITOR Usage And Synthesis
Uses
gamma-Secretase Inhibitor I is a γ-secretase inhibitor.
Biological Activity
Cell permeable: yes', 'Primary Target
γ-secretase', 'Product does not compete with ATP.', 'Reversible: no
in vivo
Z-LLNle-CHO (5 mg/kg; s.c.; single daily for 12 days) inhibits engraftment of B-lymphoblasts in precursor-B ALL xenograft model[2].
| Animal Model: | Female SCID/NOD mice (6-8-week-old; precursor-B ALL xenograft model)[2]. |
| Dosage: | 5 mg/kg |
| Administration: | Subcutaneous injection; single daily for 12 days |
| Result: | Delayed or prevented engraftment of B-lymphoblasts in 50% of the animals comprising the experimental group. |
GAMMA-SECRETASE INHIBITORSupplier
Alabiochem Tech.Co., Ltd.
- Tel
- 512-58900862 400-0707518
- sales@alabiochem.com
VDM Biochemicals
- Tel
- 0330-2528181
- sales@vdmbio.com
Chemsky (shanghai) International Co.,Ltd
- Tel
- 021-50135380
- shchemsky@sina.com
Hunan Hui Bai Shi Biotechnology Co., Ltd.
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
Nanjing Dulai Biotechnology Co., Ltd.
- Tel
- 025-846993838003-8003 18013301590
- njduly@126.com
More
Less
GAMMA-SECRETASE INHIBITOR(133407-83-7)Related Product Information
- DAPT
- DIBENZAZEPINE
- γ-Secretase Inhibitor XXI
- BETA-SECRETASE INHIBITOR IV
- N-Cbz-D-glutamic acid alpha-benzyl ester
- N-Carbobenzyloxy-L-alanine
- Z-D-ASP(OTBU)-OH H2O
- Z-NVA-OH
- Z-PHE-ALA-DIAZOMETHYLKETONE
- Z-SAR-OH
- GAMMA-SECRETASE INHIBITOR XVI
- GAMMA-SECRETASE INHIBITOR XV
- GAMMA-SECRETASE INHIBITOR XVII
- GAMMA-SECRETASE INHIBITOR XI
- GAMMA-SECRETASE INHIBITOR VII
- GAMMA-SECRETASE INHIBITOR X
- GAMMA-SECRETASE INHIBITOR XVIII
- GAMMA-SECRETASE INHIBITOR XIX