O-BENZYL-L-SERINE METHYL ESTER HYDROCHLORIDE
O-BENZYL-L-SERINE METHYL ESTER HYDROCHLORIDE Basic information
- Product Name:
- O-BENZYL-L-SERINE METHYL ESTER HYDROCHLORIDE
- Synonyms:
-
- O-BENZYL-L-SERINE METHYL ESTER HYDROCHLORIDE
- METHYL O-BENZYL-L-SERINATE HYDROCHLORIDE
- H-SER(BZL)-OME HCL
- Benzylserinemethylesterhydrochloride
- o-benzyl-l-serinemethylesterHCl
- methyl (2S)-2-amino-3-(benzyloxy)propanoate hydrochloride
- Methyl O-Benzyl-L-serinate Hydrochloride H-Ser(Bzl)-OMe.HCl
- O-Benzyl-L-serine Methyl Ester Hydrochloride
- CAS:
- 19525-87-2
- MF:
- C11H16ClNO3
- MW:
- 245.7
- EINECS:
- 1533716-785-6
- Product Categories:
-
- Biochemistry
- Amino Acid Methyl Esters
- Amino Acids
- Amino Acids (C-Protected)
- Mol File:
- 19525-87-2.mol
O-BENZYL-L-SERINE METHYL ESTER HYDROCHLORIDE Chemical Properties
- Melting point:
- 164-166 °C
- refractive index
- 5 ° (C=1, MeOH)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- color
- White to Almost white
- Water Solubility
- almost transparency
- InChI
- InChI=1/C11H15NO3.ClH/c1-14-11(13)10(12)8-15-7-9-5-3-2-4-6-9;/h2-6,10H,7-8,12H2,1H3;1H/t10-;/s3
- InChIKey
- UDHSAWHYRXHQJP-MEQOOBBNNA-N
- SMILES
- C1(=CC=CC=C1)COC[C@H](N)C(=O)OC.Cl |&1:9,r|
- CAS DataBase Reference
- 19525-87-2
Safety Information
- Safety Statements
- 24/25
- HS Code
- 2922.50.4000
O-BENZYL-L-SERINE METHYL ESTER HYDROCHLORIDE Usage And Synthesis
Uses
O-Benzyl-L-serine Methyl Ester Hydrochloride is a reactant used in the synthesis of ureidopeptides and peptidyl ureas.
Synthesis
23680-31-1
19525-87-2
Example 44A: 300 mg (1.02 mmol) of (S)-3-benzyloxy-2-tert-butoxycarbonylamino-propionic acid was dissolved in 10 mL of dichloromethane (DCM) at 0 °C and 1.5 mL (20.5 mmol) of thionyl chloride was added slowly. The reaction mixture was stirred at 0°C for 14 hours. Upon completion of the reaction, the mixture was concentrated, followed by addition of methanol and evaporation several times to give O-benzyl-L-serine methyl ester hydrochloride as a white solid. Yield: 270 mg (100%).LC-MS (Method 1s): retention time (RT) = 0.92 min, MS (ESI pos): m/z = 210 (M + H)+.
References
[1] Patent: WO2009/92566, 2009, A1. Location in patent: Page/Page column 112-113
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O-BENZYL-L-SERINE METHYL ESTER HYDROCHLORIDE(19525-87-2)Related Product Information
- L-Serine methyl ester hydrochloride
- H-Ser-OtBu · HCl
- H-SER(TBU)-OH
- H-D-SER(TBU)-OH
- H-D-SER(TBU)-OTBU HCL
- L-Ser-OBzl.HCl
- O-tert-Butyl-L-serine methyl ester hydrochloride
- O-BENZYL-D-SERINE
- H-D-SER-OBZL HCL
- O-tert-Butyl-D-serine methyl ester hydrochloride
- H-SER-SER-OH
- L-Serine,O-(triphenylmethyl)-
- H-SER(TBU)-OTBU HCL
- H-SER-ALA-OH
- H-Ser(tBu)-OBzl.HCl
- O-ACETYL-L-SERINE
- H-Ser(SO3H)-OH.HCl
- O-BENZYL-L-SERINE