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L-Ser-OBzl.HCl

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L-Ser-OBzl.HCl Basic information

Product Name:
L-Ser-OBzl.HCl
Synonyms:
  • SERINE-OBZL HCL
  • L-SERINE BENZYL ESTER HYDROCHLORIDE
  • H-SER-OBZL HCL
  • benzyl 2-aMino-3-hydroxypropanoate hydrochloride
  • H-SER-OBZL·HCL
  • L-SerinebenzylesterHCl
  • L-Serine benzyl ester hydrochloride≥ 99% (TLC)
  • L-β-Hydroxyalanine benzyl ester hydrochloride
CAS:
60022-62-0
MF:
C10H14ClNO3
MW:
231.68
Product Categories:
  • Amino Acid Benzyl Esters
  • Amino Acids
  • Amino Acids (C-Protected)
  • Biochemistry
Mol File:
60022-62-0.mol
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L-Ser-OBzl.HCl Chemical Properties

Melting point:
175°C
refractive index 
-12 ° (C=1, H2O)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
form 
powder to crystal
color 
White to Almost white
Water Solubility 
Soluble in water.
InChI
InChI=1/C10H13NO3.ClH/c11-9(6-12)10(13)14-7-8-4-2-1-3-5-8;/h1-5,9,12H,6-7,11H2;1H/t9-;/s3
InChIKey
MGZWCDQAKCHOBX-FVGYRXGTSA-N
SMILES
C(OCC1=CC=CC=C1)(=O)[C@H](CO)N.[H]Cl |&1:10,r|
CAS DataBase Reference
60022-62-0(CAS DataBase Reference)
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29225090

MSDS

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L-Ser-OBzl.HCl Usage And Synthesis

Description

L-Serine benzyl ester hydrochloride, also known as L-Serine-Bz-HCl, is a derivative of the amino acid L-Serine. It is a water-soluble, white crystalline powder and is commonly used as a reagent in biochemical and physiological studies. It is a useful raw material that could synthesize mang organic compounds, such as a cyclic sulfamidate which could reacted cleanly with the sodium thiolate salt of a variety of unprotected 1-thio sugars in aqueous buffer to afford the corresponding S-linked amino acid glycoconjugates in good yields after hydrolysis of the N-sulfates[1].

Chemical Properties

Colorless solid

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Preparation

Boc-L-Ser-OBz (2.953 g, 10 mmol) was dissolved in MeOH (21 mL) and was palced in ice bath. Then concentrated hydrochloric acid (4.25 mL) was added dropwise. The ice bath was removed and the reaction mixture was stirred for 3 hours. After that the isopropanol (10 mL) was added and the volatile components were removed under reduced pressure at 55 ℃. The oily residue was coevaporated with isopropanol three times (3x10 mL). L-Serine benzyl ester hydrochloride ( yield=69%) was crystallized from H2O/iPr-OH/acetone mixture.

References

[1] Cohen S, et al. Synthesis of S-linked glycosyl amino acids in aqueous solution with unprotected carbohydrates. Organic Letters, 2001; 3: 405–407.

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