Benzyl nicotinate Chemical Properties

Melting point:

24 °C (lit.)

Boiling point:

177 °C/8 mmHg (lit.)

Density 

1,1165 g/cm³

refractive index 

n20/D 1.570

Flash point:

170°C

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Sparingly), Methanol (Slightly)

form 

<24°C Solid,>24°C Liquid

pka

3.16±0.10(Predicted)

color 

Colourless to Light Beige

Merck 

14,6526

BRN 

159169

LogP

2.400

CAS DataBase Reference

94-44-0(CAS DataBase Reference)

NIST Chemistry Reference

Nicotinic acid, benzyl ester(94-44-0)

EPA Substance Registry System

3-Pyridinecarboxylic acid, phenylmethyl ester (94-44-0)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/38

Safety Statements 

26

WGK Germany 

2

RTECS 

QT0850000

F 

8

TSCA 

Yes

HS Code 

2933399990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Benzyl nicotinate Usage And Synthesis

Chemical Properties

Benzyl nicotinate is a benzyl ester resulting from the formal condensation of the carboxy group of nicotinic acid with benzyl alcohol. It derives from a nicotinic acid. It is a vasodilator agent and is also generally used in cosmetics and drugs.It has been used as a rubefacient.
Benzyl nicotinate can be used for the synthesis of benzylpalladium complexes to be used as catalysts for the substitution of olefins with benzylic groups.

Uses

benzyl nicotinate can increase skin oxygenation—thanks to vasodilatation properties—and help stimulate the healing process of wounded skin. It is an ester form of niacin (vitamin B), benzyl alcohol, and nicotinic acid.

Uses

Benzyl nicotinate can be used for the synthesis of benzylpalladium complexes to be used as catalysts for the substitution of olefins with benzylic groups.

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Definition

ChEBI: A benzyl ester resulting from the formal condensation of the carboxy group of nicotinic acid with benzyl alcohol. It has been used as a rubefacient.

Synthesis Reference(s)

Synthetic Communications, 14, p. 515, 1984 DOI: 10.1080/00397918408059573

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Benzyl Nicotinate is a medication widely used as a vasodilator, that widens blood vessels. It basically oxygenates and flushes the skin′s capillaries.

Clinical Use

Benzyl nicotinate is used in combination with heparin in the treatment of inflammation of vein (thrombophlebitis), pain in dilated veins area, pains and cramps in the leg muscles, disturbances of lymph circulation, traffic and sports related injuries, postoperative and posttraumatic scars, non-joint rheumatism or soft tissue rheumatism.

Benzyl nicotinate(94-44-0)Related Product Information

• Benzyl chloride
• Benzyl alcohol
• Pyridine
• Inositol nicotinate
• Benzyl benzoate
• Vitamin E nicotinate
• Benzyl formate
• Benzoyl peroxide
• VITAMIN E NICOTINATE
• Benzyl chloroformate
• Benzyl acetate
• RESMETHRIN
• Nicotinamide riboside chloride
• Chromium nicotinate
• Hexyl nicotinate
• N-BUTYL NICOTINATE
• Ethyl nicotinate
• Methyl nicotinate